Results 201 to 210 of about 1,062,874 (251)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

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GOOD CLINICAL PRACTICE IN CLINICAL RESEARCH

Lancet, The, 1989
S L, Nightingale, F O, Kelsey
exaly   +5 more sources

IS GOOD CLINICAL RESEARCH PRACTICE FOR CLINICAL TRIALS GOOD CLINICAL PRACTICE?

International Journal of Geriatric Psychiatry, 1997
This article presents results of monitoring of the recruitment process for a phase III study of a new antidepressant drug in elderly patients with depressive disorders, focusing on the peculiarities of recruitment posed by the presence of comorbidity and coadministration of medications.
O, Yastrubetskaya, E, Chiu, S, O'Connell
openaire   +2 more sources

Good Clinical Practice

2014
Klinisch geneesmiddelenonderzoek moet uitgevoerd worden volgens het strikte richtsnoer van good clinical practice (GCP). Dit is een internationale ethische en wetenschappelijke kwaliteitsstandaard voor het opzetten, uitvoeren, vastleggen en rapporteren van klinisch geneesmiddelenonderzoek waaraan proefpersonen deelnemen. In dit hoofdstuk beschrijven we
  +4 more sources

Good clinical practice in orthokeratology

Contact Lens and Anterior Eye, 2008
Overnight orthokeratology is becoming more and more popular especially in the Asia-Pacific region where the treatment is primarily used for myopic control in young children. Risk of complications in contact lens wear increases during overnight wear and may further increase when the treatment is used on children.
Pauline, Cho, Sin Wan, Cheung, John, Mountford, Peter, White   +3 more
openaire   +2 more sources

Good Clinical Practice

2013
Good Clinical Practice (GCP) is a set of guidelines for trial research, not for the practice of clinical care, as the name might suggest. This chapter aims to introduce the large topic of GCP, to orient those researchers who are unfamiliar with trial research to the essence and scope of GCP guidelines, and to discuss some practical GCP-related tasks ...
Jan Van den Broeck, Vundli Ramokolo, Jutta Dierkes   +2 more
openaire   +2 more sources