Results 181 to 190 of about 14,696,344 (291)

Good Clinical Trials by removing defensive interpretation of Good Clinical Practice guidelines. [PDF]

Br J Clin Pharmacol, 2021
den Heijer JM, Heuberger JAAC, Hijma H, Kruithof AC, van Smeden J, Groeneveld GJ, Burggraaf J, Cohen A.   +7 more
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Implementation of good clinical practice in clinical research in the context of limited resources settings: Lessons learnt from the freeBILy trial using an embedded mixed methods approach. [PDF]

PLoS Negl Trop Dis
Gunga L, Rausche P, Rakotoarivelo RA, Rasamoelina M, Solonirina J, Fesia E, Razafindrakoto R, Rakotozandrindrainy N, Radomanana M, Marchese V, Issa N, Kutz JM, Remkes A, Jager A, Puraduredja DI, van Dam G, Schwarz N, May J, Rakotozandrindrainy R, Fischer N, Fusco D, freeBILy consortium.   +21 more
europepmc   +1 more source

Publisher Correction: Descriptive Analysis of Good Clinical Practice Inspection Findings from U.S. Food and Drug Administration and European Medicines Agency. [PDF]

Ther Innov Regul Sci, 2022
Sellers JW, Mihaescu CM, Ayalew K, Kronstein PD, Yu B, Ning YM, Rodriguez M, Williams L, Khin NA.   +8 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Evaluating the Impact of a Good Clinical Practice Workshop on the Knowledge and Attitude of Postgraduate Medical Students. [PDF]

Cureus
Patel A, Padarya SK, Virani A, Singh P.
europepmc   +1 more source

FIGO good clinical practice paper: management of the second stage of labor. [PDF]

Int J Gynaecol Obstet, 2021
Wright A, Nassar AH, Visser G, Ramasauskaite D, Theron G, FIGO Safe Motherhood and Newborn Health Committee.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Integrating ICH Good Clinical Practice (GCP) Principles and Essential Documentation into Dermatology Residency Education in China. [PDF]

Adv Med Educ Pract
Ding X, Wang P, Tao X, Tang Y.
europepmc   +1 more source

ISP Good Clinical Practice Recommendations for the management of Dentin Hypersensitivity.

J Indian Soc Periodontol, 2022
Grover V, Kumar A, Jain A, Chatterjee A, Grover HS, Pandit N, Satpathy A, Madhavan Pillai BR, Melath A, Dhruvakumar D, Thakur R, Joshi NV, Deshpande N, Dadlani H, Meenakshi AA, Ashok KP, Reddy KV, Bhasin MT, Salaria SK, Verma A, Gaikwad RP, Darekar H, Amirisetty R, Phadnaik M, Karemore V, Dhulipalla R, Mody D, Rao TS, Chakarpani S, Ranganath V.   +29 more
europepmc   +1 more source