Results 171 to 180 of about 1,091,889 (296)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

www.medevphv.net

, 2008
An e-learning system focused on pharmacovigilance science and regulation which has been developed, tested and validated during the project with the active support of three levels of end-users (the SMEs, the Health practitioners and the Pharmaceutical ...
European Forum for Good Clinical Practice, RUBERTO, MARIA GIOVANNA, Pasteur Mediavita, Institut National de la Santé et de la Recherche Médicale, Arisoft editorial, Gruppo S. Lab, Tecnofarmaci   +6 more
core  

Implementation of good clinical practice in clinical research in the context of limited resources settings: Lessons learnt from the freeBILy trial using an embedded mixed methods approach. [PDF]

PLoS Negl Trop Dis
Gunga L, Rausche P, Rakotoarivelo RA, Rasamoelina M, Solonirina J, Fesia E, Razafindrakoto R, Rakotozandrindrainy N, Radomanana M, Marchese V, Issa N, Kutz JM, Remkes A, Jager A, Puraduredja DI, van Dam G, Schwarz N, May J, Rakotozandrindrainy R, Fischer N, Fusco D, freeBILy consortium.   +21 more
europepmc   +1 more source

Development of a Good Clinical Practice inspection checklist to assess clinical trial sites in Vietnam. [PDF]

BMJ Open, 2021
Nguyen QN, Nguyen NV, Nguyen DTP, Vidaillac C, Trinh PTM, van Doorn HR, Thwaites GE, Kestelyn E, Vo HTN.   +8 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Monitoring of invasive assisted mechanical ventilation: a good clinical practice document by the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI). [PDF]

J Anesth Analg Crit Care
Colombo D, Ippolito M, Bellani G, Battaglini D, Cammarota G, Cortegiani A, Giarratano A, Grasso S, Maggiore SM, Mirabella L, Navalesi P, Rauseo M, Simonte R, Spadaro S, Spinazzola G, Grasselli G.   +15 more
europepmc   +1 more source

Publisher Correction: Descriptive Analysis of Good Clinical Practice Inspection Findings from U.S. Food and Drug Administration and European Medicines Agency. [PDF]

Ther Innov Regul Sci, 2022
Sellers JW, Mihaescu CM, Ayalew K, Kronstein PD, Yu B, Ning YM, Rodriguez M, Williams L, Khin NA.   +8 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Good Clinical Trials by removing defensive interpretation of Good Clinical Practice guidelines. [PDF]

Br J Clin Pharmacol, 2021
den Heijer JM, Heuberger JAAC, Hijma H, Kruithof AC, van Smeden J, Groeneveld GJ, Burggraaf J, Cohen A.   +7 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source