Results 151 to 160 of about 14,696,344 (291)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Quality requirements in clinical studies: a necessary burden?

Swiss Medical Weekly, 2003
M Salzberg
doaj   +1 more source

Evidence-Based Medicine and Good Clinical Practice in Research in Pediatric and Adolescent Medicine. [PDF]

Children (Basel)
Karatza AA, Tsintoni A, Kapnisis D, Gkentzi D, Fouzas S, Kostopoulou E, Sinopidis X, Antonakopoulos N.   +7 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Indian Society of Periodontology Good Clinical Practice Recommendations for dental pain management and use of analgesics. [PDF]

J Indian Soc Periodontol
Grover V, Kumar A, Satpathy A, Jain A, Deshpande N, Grover HS, Khatri M, Nandkeoliar T, Nair A, Benjamin A, Nichani AS, Singh B, Dave BD, Bhutada G, Chahal GS, Sangha KS, Debnath T, Damera TK, Karemore V, Sheokand V, Bains VK.   +20 more
europepmc   +1 more source

Report of the Council of the University of the Cape of Good Hope eighteen ninety five

, 2015
Report of the proceedings of the University of the Cape of Good Hope during 1895.Official 1895 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.

core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Bridging the gap in clinical research training: a qualitative study of postgraduate medical students' perceptions of good clinical practice education. [PDF]

Med Educ Online
Xiaoyun W, Zhao Y, Zeyun L, Chen X, Xuedong J, Yaowen L, Jie W, Xin T.   +7 more
europepmc   +1 more source

Survey Results and Recommendations from Japanese Stakeholders for Good Clinical Practice Renovation. [PDF]

Ther Innov Regul Sci, 2022
Nakamura K, Ozawa H, Shibata T, Ushirozawa N, Hata T, Okita N, Fuse N, Sato N, Ikeda K, Hanaoka H, Maruyama T, Wada M, Shimizu S, Kasai H, Yamamoto Y, Sakurai J, Todaka K, Tashiro S, Yamamoto H.   +18 more
europepmc   +1 more source

Good Clinical Practice and Good Laboratory Practice

, 2009
Nathalie K. Zgheib, Stephanie L. Tomasic, Robert A. Branch   +2 more
openaire   +1 more source