Results 131 to 140 of about 1,062,874 (251)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A 7-Year Analysis of the U.S. FDA Good Clinical Practice Inspection Outcomes for Marketing Applications. [PDF]

Ther Innov Regul Sci
McGuire C, Sellers JW, Muldowney L.
europepmc   +1 more source

Good Clinical Practice of the Italian Society of Thalassemia and Haemoglobinopathies (SITE) for the Management of Endocrine Complications in Patients with Haemoglobinopathies. [PDF]

J Clin Med, 2022
Casale M, Baldini MI, Del Monte P, Gigante A, Grandone A, Origa R, Poggi M, Gadda F, Lai R, Marchetti M, Forni GL.   +10 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Monitoring of invasive assisted mechanical ventilation: a good clinical practice document by the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI). [PDF]

J Anesth Analg Crit Care
Colombo D, Ippolito M, Bellani G, Battaglini D, Cammarota G, Cortegiani A, Giarratano A, Grasso S, Maggiore SM, Mirabella L, Navalesi P, Rauseo M, Simonte R, Spadaro S, Spinazzola G, Grasselli G.   +15 more
europepmc   +1 more source

Development of a Good Clinical Practice inspection checklist to assess clinical trial sites in Vietnam. [PDF]

BMJ Open, 2021
Nguyen QN, Nguyen NV, Nguyen DTP, Vidaillac C, Trinh PTM, van Doorn HR, Thwaites GE, Kestelyn E, Vo HTN.   +8 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Publisher Correction: Descriptive Analysis of Good Clinical Practice Inspection Findings from U.S. Food and Drug Administration and European Medicines Agency. [PDF]

Ther Innov Regul Sci, 2022
Sellers JW, Mihaescu CM, Ayalew K, Kronstein PD, Yu B, Ning YM, Rodriguez M, Williams L, Khin NA.   +8 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Is Good Clinical Practice Becoming Poor Clinical Care?

HemaSphere, 2017
Steven Le Gouill, Martin Dreyling, Maria Dolores Caballero, Marc Andre, Jeannette Doorduijn, Wojciech Jurczak, Mats Jerkeman, Paolo Ghia, Pier-Luigi Zinzani, Maria Gomez Da Silva, Meletios Dimopoulos, Marek Trneny, Richard Delarue, Jan Walewski, Christian Gisselbrecht, Armando López-Guillermo, Simon Rule   +16 more
doaj   +1 more source