Results 141 to 150 of about 14,696,344 (291)

The development of a good clinical practice training model for use in South African clinical trials

, 2005
Philosophiae Doctor - PhDMedicines for human use worldwide are generated in part through the conduct of clinical trials. This is done to ensure safety and efficacy.
Raphesu, Nomusa Joyce
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Management goals of type 1 Gaucher disease in South Africa: An expert Delphi consensus document on good clinical practice. [PDF]

PLoS One, 2023
Louw VJ, Fraser I, Giraldo P.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

ESMO and ASCO Consensus on Good Clinical Practice Guideline E6(R3): A Step Forward Towards Streamlining Clinical Research. [PDF]

ESMO Open
Perez-Gracia JL, Levit L, Sanmamed MF, Sharma P, André F, Hosius C, Patel B, Nuti A, Carey L, Amaral T.   +9 more
europepmc   +1 more source

Good clinical practice improves rigor and transparency: Lessons from the ACTIVE trial. [PDF]

Psychol Aging, 2022
Taylor BP, Rebok GW, Marsiske M.
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Good Clinical Practice Guidance for Line Materials, Filtration, and Light Protection in Intravenous Medication Administration: Modified Delphi Consensus Study. [PDF]

JMIR Hum Factors
Dickman A, Tuffin P, Al-Jaber R, El-Harmeel M, Schneider J, Taladriz-Sender I, Sutherland A, Terkola R, Waterson J.   +8 more
europepmc   +1 more source

Good clinical practice recommendations in allergen immunotherapy: Position paper of the Brazilian Association of Allergy and Immunology - ASBAI. [PDF]

World Allergy Organ J, 2022
Aarestrup FM, Taketomi EA, Santos Galvão CE, Gagete E, Nóbrega Machado Arruda AC, Alves GB, Véras de Araújo Gueiros Lira G, Gonçalves MR, Couto Miziara MG, Maranhão Casado SS, Curi SV, Rufino Pereira VA, Sales V, Solé D, de Paula Motta Rubini N, Cavalcanti Sarinho ES.   +15 more
europepmc   +1 more source

Pharmacokinetic studies of neuromuscular blocking agents: Good Clinical Research Practice (GCRP)

, 2000
Good Clinical Research Practice (GCRP), neuromuscular blocking agents, pharmacokinetics, pharmacokinetic/pharmacodynamic modeling, population pharmacokinetics, statistics, study ...
Østergaard, D., Rasmussen, S.N., Proost, J.H., Donati, F., Viby-Mogensen, J., Fisher, D., Kopman, A., Varin, F., Kampmann, J.P., Skovgaard, Lene Theil, Hunter, J., Wright, P.M.C.   +11 more
core