Results 161 to 170 of about 14,696,344 (291)

Good Clinical Practice [PDF]

Journal of pharmacology & clinical research, 2019
openaire   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Evolving Standards: Good Clinical Practice Insights from US FDA, MHRA UK, and Health Canada. [PDF]

Clin Pharmacol Ther
Grandinetti C, Budwal-Jagait M, Abid H, Gebbia E, Boley E, Williams L, Fisher A, Marcus L, Muldowney L, Sellers J, Wakelin-Smith J, Ayalew K.   +11 more
europepmc   +1 more source

"How do I keep this live in my mind?" Allied Health Professionals' perspectives of barriers and enablers to implementing good clinical practice principles in research: a qualitative exploration. [PDF]

BMC Health Serv Res, 2023
Wenke R, Roberts S, Angus R, Owusu MA, Weir K.   +4 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Concordance between European medicine agency good clinical practice inspections and medical literature: a meta-research survey. [PDF]

BMC Med
Terré A, Becker O, Ioannidis JPA, Naudet F.   +3 more
europepmc   +1 more source

Correction to: Descriptive Analysis of Good Clinical Practice Inspection Findings from U.S. Food and Drug Administration and European Medicines Agency. [PDF]

Ther Innov Regul Sci, 2022
Sellers JW, Mihaescu CM, Ayalew K, Kronstein PD, Yu B, Ning YM, Rodriguez M, Williams L, Khin NA.   +8 more
europepmc   +1 more source

Report of the Council of the University of the Cape of Good Hope eighteen ninety six

, 2015
Report of the proceedings of the University of the Cape of Good Hope during 1896.Official 1896 Report of the Council of the University of the Cape of Good Hope to the Cape Colonial Parliament.

core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Good Clinical Practice of the Italian Society of Thalassemia and Haemoglobinopathies (SITE) for the Management of Endocrine Complications in Patients with Haemoglobinopathies. [PDF]

J Clin Med, 2022
Casale M, Baldini MI, Del Monte P, Gigante A, Grandone A, Origa R, Poggi M, Gadda F, Lai R, Marchetti M, Forni GL.   +10 more
europepmc   +1 more source