Results 91 to 100 of about 1,072,193 (286)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Why death can be bad and immortality is worse
, 2009 This thesis examines the moral implications of the metaphysical nature of death. I begin with the Epicurean arguments which hold that death is morally irrelevant for the one who dies, and that one should regard it accordingly.
Kalnow, Cara
core
Conceptual analysis of good death expectations in older adults
Huli yanjiuObjectiveTo conduct an in⁃depth analysis of older adults' expectations for a "good death" using Rodgers' evolutionary concept analysis method, aiming to better understand and fulfill their end⁃of⁃life care wishes and help them achieve a good death ...
LI Yanping +4 more
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Good Life and Good Death: Palliative Pursuit of Chinese Life Culture
Xiehe Yixue ZazhiChinese traditional life culture, based on the unity of life and death, has a set of cultural narrative of 'Peace' at the end of life. In terms of the fundamental concept, it argues that 'Death' is more important than 'Health care', and 'Good death' is ...
HE Renfu
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 2012 This is an open access Article. Copyright @ 2012 The AuthorsAn increased risk of death in persons who have suffered spousal bereavement has been described in many populations.
Harris, T +6 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
“Can’t you at least die with a little dignity?” The Right to Die Debates and Normative Dignity
BioéthiqueOnline, 2014 In recent decades, the right to die has emerged as one of the most divisive social and political questions in North America and Europe, one that involves the mobilization of numerous social actors and activists as well as several legal challenges. In Qué
Gandsman, Ari, Burnier, Daniel
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