Results 111 to 120 of about 1,072,193 (286)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Perception of Good Death and Level of Perceived Stress in Relatives of Palliative Care Patients

open access: yes
This study aimed to examine the perception of a good death and the level of perceived stress in relatives of palliative care patients. Relatives of 110 patients hospitalized in a palliative care center constituted the research sample.
Pamuk Cebeci, Sevil, Bilgic, Sebnem
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Human Aging as a Creational Good: Interactions between Theology and Molecular Biology

open access: yesZygon
A Christian theology of human aging faces significant challenges. First, aging receives far less theological attention than the heavily related and well-established themes of creation, sin, death, and imago Dei.
David James Hooker
doaj   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Status quo of expectations for good death in elderly patients with chronic comorbidities

open access: yesHuli yanjiu
ObjectiveTo understand the status quo of expectations for a good death in elderly patients with chronic comorbidities.MethodsA total of 282 elderly patients with chronic comorbidities treated at a geriatric hospital in Yunnan province were conveniently ...
ZHANG Jingmin   +4 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

The death of good faith in registration

open access: yesThēmis, 2015
The article 2014 of the Civil Code has been recently modified.  In  order  to  make this decision, the legislator took in consideration two reasons: theaffirmation that the record entry doesn’t countswith its own substantivity, and that the necessityof ...
Freddy Escobar Rozas
doaj  

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