Results 141 to 150 of about 1,022,284 (249)

Notion of a good death for patients with cancer: a qualitative systematic review protocol. [PDF]

BMJ Open, 2022
Xiao J, Ding J, Huang C.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Defining a Good Death in the Intensive Care Unit: A Systematic Review. [PDF]

Indian J Palliat Care
Hafifah I, Wisesrith W, Ua-Kit N, Ho BM.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The perceptions on good death of the older adults in the semi-urban community: A qualitative study. [PDF]

Int J Nurs Sci, 2022
Tipwong A, Ruamsook T, Hongkittiyanon T, Kgowsiri K.   +3 more
europepmc   +1 more source

Psychometric Evaluation of the Good Death Index from Patients with Terminal Cancer’s Perspectives: A Mixed-Methods Study

Journal of Multidisciplinary Healthcare
Shih-Hsuan Pi,1– 3 In-Fun Li,4,5 Pei-Yi Li,6 Yuen-Liang Lai,7 Chun-Kai Fang6– 9 1Department of Medical Research, Tamsui Branch, MacKay Memorial Hospital, New Taipei, Taiwan; 2General Education Center, MacKay Junior College of Medicine, Nursing, and ...
Pi SH, Li IF, Li PY, Lai YL, Fang CK
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

[The importance of life stories in the care for a good death]. [PDF]

An Sist Sanit Navar
Ochando Ortiz G.
europepmc   +1 more source

Values of Australian Meat Consumers Related to Sheep and Beef Cattle Welfare: What Makes a Good Life and a Good Death? [PDF]

Food Ethics, 2023
Buddle EA, Bray HJ, Ankeny RA.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source