Results 151 to 160 of about 1,072,193 (286)

Digital Framing in End-of-Life Communication: Constructing "Good Death" Support in the Discourse of Hospice Care Institutions in the UK and Hong Kong. [PDF]

Healthcare (Basel)
Wan YN, Forey G, Zeng W.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

"It sounds unfamiliar, yet appealing": a qualitative study on perceptions of a good death and hospice care needs among older adults in remote rural China. [PDF]

BMC Palliat Care
Yu H, Song L, Wu Y.
europepmc   +1 more source

Translation and psychometric evaluation of the Persian version of "good death inventory- short Form" from the perspective of family-members of cancer patients. [PDF]

BMC Psychol, 2023
Roshan HM, Ebadi A, Karimi L, Barasteh S.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Intensive care nurses' perceptions of good death and end-of-life care attitudes and behaviors: a descriptive and correlational quantitative study. [PDF]

BMC Palliat Care
Bayram R, Kiziltan B.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Investigation of Nursing Students’ Attitudes Towards Perceptions of Good Death

Journal of Nursology, 2022
Duygu BAYRAKTAR , Ülkü GÜNEŞ, Burcu BAYRAKTAR BALIKÇI, Leyla KHORSHID   +3 more
doaj   +1 more source

Barriers, facilitators and unmet needs for achieving a good death and enhancing end-of-life care in the Catalan Health System: a qualitative study. [PDF]

BMJ Open
Serra-Sutton V, Fernández-Giner L, Caldeiro M, García-Altès A, Espallargues M.   +4 more
europepmc   +1 more source