Results 171 to 180 of about 1,072,193 (286)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Cross-cultural adaption and psychometric validation of Importance of Good Death-Indonesian version for patients with advanced cancer. [PDF]

Asia Pac J Oncol Nurs
Sulistyarini WD, Fan SY, Huang MC, Effendy C, Xu D, Chen TJ, Kao CY.   +6 more
europepmc   +1 more source

The perceptions on good death of the older adults in the semi-urban community: A qualitative study. [PDF]

Int J Nurs Sci, 2022
Tipwong A, Ruamsook T, Hongkittiyanon T, Kgowsiri K.   +3 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

[The importance of life stories in the care for a good death]. [PDF]

An Sist Sanit Navar
Ochando Ortiz G.
europepmc   +1 more source

Values of Australian Meat Consumers Related to Sheep and Beef Cattle Welfare: What Makes a Good Life and a Good Death? [PDF]

Food Ethics, 2023
Buddle EA, Bray HJ, Ankeny RA.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Assessing prioritization of a good death across Brazil, Italy, Japan, and the United States: A psychometric evaluation. [PDF]

Death Stud
Clem SE, Becker TD, Sacco P, Cagle JG.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

"Don't need resuscitate" in palliative care: Ethical challenge or obstacle to a good death. [PDF]

Asia Pac J Oncol Nurs
Babaie M, Farahani AS, Rassouli M.
europepmc   +1 more source