Results 51 to 60 of about 369,312 (287)

A best-fit probability distribution for the estimation of rainfall in northern regions of Pakistan

Open Life Sciences, 2016
This study was designed to find the best-fit probability distribution of annual maximum rainfall based on a twenty-four-hour sample in the northern regions of Pakistan using four probability distributions: normal, log-normal, log-Pearson type-III and ...
Amin M. T., Rizwan M., Alazba A. A.
doaj   +1 more source

Goodness-of-Fit Tests to study the Gaussianity of the MAXIMA data

, 2003
Goodness-of-Fit tests, including Smooth ones, are introduced and applied to detect non-Gaussianity in Cosmic Microwave Background simulations. We study the power of three different tests: the Shapiro-Francia test (1972), the uncategorised smooth test ...
Aliaga A.M., D'Agostino R.B., E. Martinez-Gonzalez, F. Argueso, Gorski K.M., Gupta S., J. L. Sanz, L. Cayon, Rayner J.C.W., Santos M.G., Shapiro S.S., Thomas D.R.   +11 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The use of Weibull Statistics to Quantify Property Variability in Fe-3Mn-0.8C Sinter-Hardened Structurally Inhomogeneous Steels

Archives of Metallurgy and Materials, 2013
Aby uzyskać trzy warianty spiekanej stali Fe-3Mn-0.8C wytworzono mieszanki proszków: niskowęglowego żelazoman- ganu. grafitu oraz proszków żelaza firmy Hóganiis: gąbczastego - NC100.24 i rozpylanych - ABC 100.30 oraz ASC 100.29.
Cias A., Czarski A.
doaj   +1 more source

Improved EDF-Based Tests for Weibull Distribution Using Ranked Set Sampling

Mathematics, 2022
It is well known that ranked set sampling (RSS) is superior to conventional simple random sampling (SRS) in that it frequently results in more effective inference techniques.
Safar M. Alghamdi, Rashad A. R. Bantan, Amal S. Hassan, Heba F. Nagy, Ibrahim Elbatal, Mohammed Elgarhy   +5 more
doaj   +1 more source

Testing k-monotonicity of a discrete distribution. Application to the estimation of the number of classes in a population

, 2017
We develop here several goodness-of-fit tests for testing the k-monotonicity of a discrete density, based on the empirical distribution of the observations.
Giguelay, Jade, Huet, Sylvie
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Goodness-of-Fit Tests for COM-Poisson Distribution Using Stein's Characterization

Austrian Journal of Statistics
A crucial part of data analysis is to assess the adequacy of the fit of the probability models used, and such assessment is generally made using the goodness-of-fit tests.
Traison T, V S Vaidyanathan
doaj   +1 more source