Results 61 to 70 of about 317,930 (307)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Филологический класс, 2019 The research accords with the interest of modern linguistics in revealing the characteristics of national worldviews. The subject of this article is the lexical-semantic field of GOODNESS in Russian and Chinese languages.
doaj +1 more source
Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2018 The article is devoted to the consideration of the good ethics metaphysical basis. As a phenomenon whose nature is transcendent, the good reveals itself in two projective optics.
Yuliia Yu. Brodetska
doaj +1 more source
R2ucare: An R package to perform goodness-of-fit tests for capture-recapture models
bioRxiv, 2017 Assessing the quality of fit of a statistical model to data is a necessary step for conducting safe inference. We introduce R2ucare, an R package to perform goodness-of-fit tests for open single- and multi-state capture-recapture models. R2ucare also has
O. Gimenez +3 more
semanticscholar +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Moral Philosophy in the Qur’an From theViewpoint of the Risale-i Nur Said Nursi
Tsaqafah, 2013 The content of moral philosophy in Risale-i Nur Said Nursi which is derived from the Qur’an is abundant. This paper is an attempt to elaborate that moral philosophy of the Qur’an explained thoroughly in Risale-i Nur.
Jamal Ahmad Sa’id al-Marzuqi
doaj +1 more source
A review of goodness of fit tests for Pareto distributions
Journal of Computational and Applied Mathematics, 2019 Pareto distributions are the most popular models in economics and finance. Hence, it is essential to have a wide spectrum of tools for checking their goodness of fit to a given data set. This paper provides the first review of known goodness of fit tests
Jeffrey Chu, O. Dickin, S. Nadarajah
semanticscholar +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Absolute Good and the Human Goods
Philosophical Inquiry, 2003 By the absolute Good, I understand the Idea of the Good; by the human goods, I understand pleasure and reason, which have been disqualified in Plato’s “Republic” as candidates for the absolute Good (cf.R.505b-d). Concerning the Idea of the Good, we can distinguish a minimal and a maximal interpretation. According the minimal interpretation, the Idea of
openaire +2 more sources