Results 81 to 90 of about 310,473 (292)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The Problem of Evil and the Grammar of Goodness
Religions, 2018 I consider the two venerated arguments about the existence of God: the Ontological Argument and the Argument from Evil. The Ontological Argument purports to show that God’s nature guarantees that God exists.
Eric Wiland
doaj +1 more source
When are Goods More Goods? [PDF]
Economica, 1958 It is here implied that if A is chosen rather than B, A represents more (or not fewer) goods than B (even if A contains less of some individual goods). This sounds rather like the converse of the axiom of nonsaturation, which states that if A contains more goods than B in the vector sense (i.e. more of some goods and less of none) then A will be chosen
openaire +1 more source
Testing EBUmgf Class of Life Distributions based on Goodness of Fit approach
Journal of Statistical Theory and Applications (JSTA), 2016 Based on the goodness of fit approach, a new test is presented for testing exponentiality against “exponential Better than Used in moment generating function ordering class” (EBUmgf). The critical values and the powers of this test are calculated.
A. Gadallah
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Archer and Aristotle’s Doctrine of the Mean
Peitho, 2012 It is sometimes claimed that Aristotle’s doctrine of the Mean is false or unhelpful: moral virtues are not typically flanked by two opposing vices as he claimed.
Glen Koehn
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Explanation of Goodness Concept in Good Governance [PDF]
مدیریت دولتی, 2009 Good governance is a fresh subjects regarded by authors and world scientific and international societies during two recent decades. Researches describe and define good governance through various approaches (process, liberalism, and socialism), dimensions
Soroush Dabbagh, Neda Nafari
doaj
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source