Results 91 to 100 of about 579,746 (284)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Goodness-of-fit tests for the Compound Rayleigh distribution with application to real data

open access: yesHeliyon, 2019
An important problem in statistics is to obtain information about the form of the population from which the sample is drawn. Goodness of fit (GOF) tests is employed to determine how well the observed sample data “fits” some proposed model. The well known
Majdah M. Badr
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

A goodness-of-fit test based on neural network sieve estimators. [PDF]

open access: yesStat Probab Lett, 2021
Shen X, Jiang C, Sakhanenko L, Lu Q.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

PEMILIHAN DISTRIBUSI PROBABILITAS PADA ANALISA HUJAN DENGAN METODE GOODNESS OF FIT TEST

open access: yesJurnal Teknik Sipil dan Perencanaan, 2016
Rainfall event is a stochastic process, so to explain and analyze this processes the probability theory and frequency analysisare used. There are four types of probability distributions.They are normal, log normal, log Pearson III and Gumbel. To find the
Togani Cahyadi Upomo, Rini Kusumawardani
doaj  

A new entropy estimator and its application to goodness of fit test for Weibull distribution [PDF]

open access: yesJournal of Mahani Mathematical Research
In this article, we introduce a new estimator of entropy of continuous random variable. Bias, variance and the mean squared error of the new estimator are obtained and compared with the other existing estimators.
Sayed Qasim Alavi   +2 more
doaj   +1 more source

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