Results 81 to 90 of about 369,312 (287)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Semiparametric Estimates and Goodness-of-Fit Tests for Tire Wear and Failure Time Data
Nonlinear Analysis, 2002 The goodness-of-fit test for tire wear and failure time data with multiple failure modes is proposed. Parametric estimators of traumatic event cumulative intensities and semiparametric estimates of various reliability characteristics are given and their ...
Rūta Levulienė
doaj +1 more source
Sobolev tests of goodness of fit of distributions on compact Riemannian manifolds
, 2005 Classes of coordinate-invariant omnibus goodness-of-fit tests on compact Riemannian manifolds are proposed. The tests are based on Gin\'{e}'s Sobolev tests of uniformity. A condition for consistency is given.
Jupp, P. E.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Goodness-of-fit tests for sparse nominal data based on grouping
Nonlinear Analysis, 2012 . For (very) sparse nominal data, common goodness-of-fit tests usually fail. Alternative goodness-of-fit tests based on extended empirical Bayes approach and grouping are proposed and their consistency is proved.
Marijus Radavičius, Pavel Samusenko
doaj
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Energy ReportsWind energy, a key renewable source, requires an accurate assessment of its resources, where the Weibull distribution stands out for its ability to model wind variability.
J. Jafet Cruz-Estudillo +4 more
doaj +1 more source
Characterizations and Goodness of Fit Tests
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1982 Summary In this article a systematic approach to providing goodness of fit tests is discussed, for the composite goodness of fit problem of testing that the distribution F of a random sample comes from a parametric family F o. Characterization procedures are emphasized, and it is shown that, at least for the exponential case, invariant ...
O'Reilly, Federico J. +1 more
openaire +2 more sources
Comparison of nonparametric goodness of fit tests [PDF]
, 1999 We consider two tests for testing the hypothesis that a density lies in a parametric class of densities and compare them by means of simulation. Both considered tests are based on the integrated squared distance of the kernel density estimator from its ...
Läuter, Henning, Sachsenweger, Cornelia
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source