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Gossypol, a natural product has good antimalarial activity of against Plasmodium falciparum clinical isolates

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Chirawurah JD   +6 more
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Gossypol and hypokalaemia

Contraception, 1985
One major side effect of administration of gossypol as a male fertility regulating agent is the occurrence of hypokalaemic paralysis. We have reviewed the common causes of hypokalaemia in clinical practice and previous studies of gossypol-induced hypokalaemia in animals and man.
C, Wang, R T, Yeung
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Gossypol inhibits testicular steroidogenesis

Fertility and Sterility, 1981
Gossypol, a compound isolated from cottonseed, has been used in the People's Republic of China as an antifertility agent in men. It was reported that gossypol is highly effective in reducing sperm count. Our study suggests that gossypol inhibits luteinizing hormone, 8-bromo-adenosine 3',5'-monophosphate-induced testosterone formation, and the ...
Lin, T. U.   +4 more
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Gossypol‐hypokalaemia interrelationships

International Journal of Andrology, 1985
Around 1% of 8806 volunteers taking gossypol as a male contraceptive had hypokalaemic paralysis and more had simple hypokalaemia, the direct cause being renal potassium loss. In gossypol takers not showing hypokalaemia, serum potassium levels were within the normal range but were significantly lower than levels in controls.
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Synthesis of gossypol and gossypol derivatives

Journal of the American Oil Chemists' Society, 1970
AbstractThe synthesis of gossypol and certain major degradation products possessing the binaphthyl ring carbon skeleton is discussed.
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The toxicology of gossypol acetic acid and (−)-gossypol

Contraception, 1988
The toxicity of gossypol has been investigated in Sprague-Dawley rats at dosages of 0, 0.5, 5.0 and 25 mg/kg per day of (+/-)-gossypol acetic acid. The most significant toxicological finding was marked suppression of body weight gain in rats receiving 25 mg/kg per day.
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