Results 211 to 220 of about 14,277 (262)

Gossypol inhibits testicular steroidogenesis

Fertility and Sterility, 1981
Gossypol, a compound isolated from cottonseed, has been used in the People's Republic of China as an antifertility agent in men. It was reported that gossypol is highly effective in reducing sperm count. Our study suggests that gossypol inhibits luteinizing hormone, 8-bromo-adenosine 3',5'-monophosphate-induced testosterone formation, and the ...
Lin, T. U., Murono, Eisuke P., Osterman, Juraj, Nankin, Howard R., Coulson, Patricia B.   +4 more
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Gossypol‐hypokalaemia interrelationships

International Journal of Andrology, 1985
Around 1% of 8806 volunteers taking gossypol as a male contraceptive had hypokalaemic paralysis and more had simple hypokalaemia, the direct cause being renal potassium loss. In gossypol takers not showing hypokalaemia, serum potassium levels were within the normal range but were significantly lower than levels in controls.
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Synthesis of gossypol and gossypol derivatives

Journal of the American Oil Chemists' Society, 1970
AbstractThe synthesis of gossypol and certain major degradation products possessing the binaphthyl ring carbon skeleton is discussed.
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The toxicology of gossypol acetic acid and (−)-gossypol

Contraception, 1988
The toxicity of gossypol has been investigated in Sprague-Dawley rats at dosages of 0, 0.5, 5.0 and 25 mg/kg per day of (+/-)-gossypol acetic acid. The most significant toxicological finding was marked suppression of body weight gain in rats receiving 25 mg/kg per day.
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Gossypol mediated DNA degradation

Biochemical and Biophysical Research Communications, 1987
Gossypol, a polyphenolic compound isolated from cotton plant was found to degrade pBR322 DNA in vitro in a reaction which required the presence of a metal ion, a reducing agent (2-mercaptoethanol) and oxygen as revealed after agarose gel electrophoresis.
Srivastava, AK, Padmanaban, G
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Gossypol Detoxication by Fungi

Science, 1969
An unidentified Diplodia isolate representative of several fungi tested and grown for 13 days on gossypol-containing cottonseed reduced the amount of free gossypol by 90 percent and detoxified the cottonseed for weanling rats and chickens.
W L, Baugher, T C, Campbell
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Resolution of racemic gossypol

Journal of the Chemical Society, Chemical Communications, 1985
Racemic gossypol, a potential antifertility agent has been resolved through its derivatives with chiral 1-methylphen-ethylamine into (+)- and (–)-gossypol.
D K, Zheng, Y K, Si, J K, Meng, J, Zhou, L, Huang   +4 more
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Resolution of racemic gossypol

Journal of Ethnopharmacology, 1987
Treating racemic gossypol with chiral amine (S)-1-methylphenethyl amine gave the expected pair of diastereomeric amino condensates in which the binaphthyl nuclei racemized during further treatment. Acetylation was applied to avoid the change. On acetylation, 7 products were separated.
L, Huang, D K, Zheng, Y K, Si
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Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats

Contraception, 1985
Thirty-nine adult male Wistar rats were administered 20 mg/kg or 24.3 mg/kg polyvinylpyrrolidone-gossypol (PVP-G) and 20 mg/kg gossypol acetic acid (G-A) 6 times a week for 6 weeks. Mating test was taken to evaluate the antifertility effect. Caudal sperm count, body weight, sex and accessory sex organ weights were recorded.
Y, Wang, X Q, Shi, Y B, Sun
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Comparative in vitro spermicidal effects of (+/-)-gossypol, (+)-gossypol, (-)-gossypol and gossypolone.

Contraception, 1985
The comparative in vitro spermicidal effects of (+)-gossypol, (-)-gossypol and (+/-)-gossypol were evaluated on the spermatozoa of human, monkey, rabbit, mouse, rat and hamster. The spermicidal effects of gossypol isomers were also compared with those of gossypolone, which is a proposed major metabolite of gossypol.
I C, Kim, D P, Waller, G B, Marcelle, G A, Cordell, H H, Fong, W H, Pirkle, L, Pilla, S A, Matlin   +7 more
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