Results 31 to 40 of about 6,673 (189)

Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. [PDF]

PLoS ONE, 2015
Gossypol, a polyphenol compound produced by cotton plant, has proven reproductive toxicity, but the effects of gossypol on sheep ovaries are unknown. This study was aimed to determine the in vitro and in vivo effects of gossypol on the ovarian follicles ...
Antônio Carlos Lopes Câmara, Ivana Cristina Nunes Gadelha, Pedro Augusto Cordeiro Borges, Silvano Alves de Paiva, Marília Martins Melo, Benito Soto-Blanco   +5 more
doaj   +1 more source

Gossypol-Capped Mitoxantrone-Loaded Mesoporous SiO₂ NPs for the Cooperative Controlled Release of Two Anti-Cancer Drugs

, 2016
Mesoporous SiO2 nanoparticles, MP-SiO2 NPs, are functionalized with the boronic acid ligand units. The pores of the MP-SiO2 NPs are loaded with the anticancer drug mitoxantrone, and the pores are capped with the anticancer drug gossypol.
Natalie Enkin (1716115), Yang Sung Sohn (1527073), Rachel Nechushtai (414787), Alexander Trifonov (1393960), Vered Heleg-Shabtai (1650313), Etery Sharon (1393957), Lina Freage (1718767), Ruth Aizen (1650310), Itamar Willner (1273365)   +8 more
core   +1 more source

Metabolomic Profiling and Network Toxicology: Mechanistic Insights into Effect of Gossypol Acetate Isomers in Uterine Fibroids and Liver Injury

Pharmaceuticals
Objective: Gossypol is a natural polyphenolic dialdehyde product that is primarily isolated from cottonseed. It is a racemized mixture of (−)-gossypol and (+)-gossypol that has anti-infection, antimalarial, antiviral, antifertility, antitumor and ...
Zishuo Liu, Hui Zhang, Jun Yao
doaj   +1 more source

Effects of Low- and High-Level Gossypol and Sodium Butyrate Supplementation Under High-Level Gossypol Condition on Growth Performance and Intestinal Health of Hybrid Grouper (Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂)

Frontiers in Marine Science, 2021
The supplementation of gossypol in excess is noted to cause detrimental effects such as the reduction of antioxidant enzymes and disruption of lipid metabolism in animals. Studies regarding the effects of different levels of gossypol are very rare; thus,
Bin Yin, Bin Yin, Bin Yin, Hongyu Liu, Hongyu Liu, Hongyu Liu, Beiping Tan, Beiping Tan, Beiping Tan, Xiaohui Dong, Xiaohui Dong, Xiaohui Dong, Shuyan Chi, Shuyan Chi, Shuyan Chi, Qihui Yang, Qihui Yang, Qihui Yang, Shuang Zhang, Shuang Zhang, Shuang Zhang   +20 more
doaj   +1 more source

Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

Biological Research, 2015
BACKGROUND: Gossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals.
Andréia T Santana, Marieli Guelfi, Hyllana C D Medeiros, Marco A Tavares, Paulo F V Bizerra, Fábio E Mingatto   +5 more
doaj   +1 more source

Gossypol's effects on ingestive behaviour in mice: The first step in a systematic process to define gossypol's suitability for use in murine pest management [PDF]

, 2014
Gossypol, synthesised by the cotton plant, Gossypium, causes physiological and behavioural changes in mammals, suggesting it may be suitable for murine pest management.
Churchill, Geoff
core  

Preclinical Efficacy and Toxicity Analysis of the Pan-Histone Deacetylase Inhibitor Gossypol for the Therapy of Colorectal Cancer or Hepatocellular Carcinoma

Pharmaceuticals, 2022
Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms.
Mascha Mayer, Alexander Berger, Christian Leischner, Olga Renner, Markus Burkard, Alexander Böcker, Seema Noor, Timo Weiland, Thomas S. Weiss, Christian Busch, Ulrich M. Lauer, Stephan C. Bischoff, Sascha Venturelli   +12 more
doaj   +1 more source

Optically active gossypol as a circular dichroism probe of interactions with serum albumins

, 1984
The (+)-enantiomer of the polyphenolic binaphthyl gossypol, has been shown to be a useful CD probe of interactions with human and bovine serum albumin.
Whaley, Kevin J., Balaram, P., Sampath, D. S.   +2 more
core   +2 more sources

A strategy for the development of varieties with the trait of high-gossypol plants with low- gossypol seeds.

, 2015
A strategy for the development of varieties with the trait of high-gossypol plants with low- gossypol seeds.
Yu Chen (29959), Quan Liu (486219), Tianzhen Zhang (76250), Yingying Wang (124944), Baoliang Zhou (461210), Jinjin Chen (725127)   +5 more
core   +1 more source

Optimization of the process parameters for reduction of gossypol levels in cottonseed meal by functional recombinant NADPH-cytochrome P450 reductase and cytochrome P450 CYP9A12 of Helicoverpa armigera

AMB Express, 2019
Gossypol is a toxic polyphenolic product that is derived from cotton plants. The toxicity of gossypol has limited the utilization of cottonseed meal (CSM) in the feed industry.
Cheng Chen, Yan Zhang, Wenhui Pi, Wenting Yang, Cunxi Nie, Jing Liang, Xi Ma, Wen-ju Zhang   +7 more
doaj   +1 more source