Results 21 to 30 of about 11,071 (224)

The embryotoxicity of gossypol [PDF]

open access: yesTeratology, 1985
AbstractIn utero development was analyzed in pregnancies that resulted from matings between gossypol‐treated male rats and untreated female rats and in pregnancies in which gossypol was administered to the pregnant rat only. Gossypol treatment of males had no effect on the outcome of pregnancy.
openaire   +3 more sources

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

open access: yes, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V.   +10 more
core   +3 more sources

Gossypol and Its Natural Derivatives: Multitargeted Phytochemicals as Potential Drug Candidates for Oncologic Diseases

open access: yesPharmaceutics, 2022
Despite the vast amounts of research and remarkable discoveries that have been made in recent decades, cancer remains a leading cause of death and a major public health concern worldwide.
Dilipkumar Pal   +4 more
doaj   +1 more source

Autophagy and urothelial carcinoma of the bladder: A review. [PDF]

open access: yes, 2016
The incidence of urothelial carcinoma of the urinary bladder (bladder cancer) remains high. While other solid organ malignancies have seen significant improvement in morbidity and mortality, there has been little change in bladder cancer mortality in the
Chandrasekar, Thenappan   +1 more
core   +2 more sources

Gossypol decreased cell viability and down-regulated the expression of a number of genes in human colon cancer cells

open access: yesScientific Reports, 2021
Plant polyphenol gossypol has anticancer activities. This may increase cottonseed value by using gossypol as a health intervention agent. It is necessary to understand its molecular mechanisms before human consumption.
Heping Cao   +3 more
doaj   +1 more source

Seminal Plasma Proteins [PDF]

open access: yes, 2012
The ejaculated semen consists of two major components viz. sperm cells (spermatozoa) and the fluid part obtained after centrifugation called seminal plasma.
P Perumal
core   +2 more sources

Conformational analysis of gossypol and its derivatives by molecular mechanics [PDF]

open access: yes, 2005
Conformations and inversion pathways leading to racemization of all the tautomers of gossypol, gossypolone, anhydrogossypol, and a diethylamine Schiff\u27s base of gossypol were investigated with MM3(2000).
Beisel, Chase   +3 more
core   +3 more sources

Isolation and characterization of a novel gossypol-degrading bacteria strain Rumen Bacillus Subtilis [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2018
Objective The aim of the study was to isolate gossypol-degrading bacteria and to assess its potential for gossypol degradation. Methods Rumen liquid was collected from fistulated cows grazing the experimental pasture.
Yunhua Zhang   +5 more
doaj   +1 more source

Preclinical Efficacy and Toxicity Analysis of the Pan-Histone Deacetylase Inhibitor Gossypol for the Therapy of Colorectal Cancer or Hepatocellular Carcinoma

open access: yesPharmaceuticals, 2022
Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms.
Mascha Mayer   +12 more
doaj   +1 more source

Synthesis, characterization and antifungal assessment of optically active bis-organotin compounds derived from (S)-BINOL diesters [PDF]

open access: yes, 2019
Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities.
Costantino, Andrea Rosana   +6 more
core   +1 more source

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