Results 61 to 70 of about 14,116 (259)
Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.The conversion of lactate to lactyl‐CoA facilitates enzymatic histone lactylation, transforming glycolytic by‐products into an epigenetic regulatory mechanism for gene expression. Lactylation modification influences macrophage polarization towards M1 or M2 phenotypes, affecting outcomes in infection, cancer and fibrosis. Targeting lactylation modifiers
Houhua Guo +5 more
wiley +1 more source
Premiers résultats de la culture "in vitro" d'ovules non fécondés de cotonnier (Gossypium hirsutum L.) [PDF]
, 1984 L'haploidisation par gynogénèse a été tentée sur Gossypium hirsutum. Après 2 a 3 mois de culture, des embryons à divers stades ont été observés dans les cavités ovulaires.
Pallarès, P.
core
Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]
, 2019 Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V. +10 more
core +2 more sources
Gossypol content of cotton free commercial feed for dairy cows
Italian Journal of Food Safety, 2015 Gossypol is a yellow pigment occurring in all parts of cotton plants, with the highest levels found in seeds, and it exhibits a variety of toxic effects.
Barbara Ricci +9 more
doaj +1 more source
Toxics, 2021 Gossypol is a key anti-nutritional factor which limits the feeding application of cottonseed by-products in animal production. A 2 × 4 factorial in vitro experiment was conducted to determine the effect of gossypol addition levels of 0, 0.25, 0.5, and 0 ...
Wei-Kang Wang +5 more
doaj +1 more source
Gossypol Affects Viral Replication by Inhibiting Pseudorabies Virus Adsorption [PDF]
, 2023 Yilin Bai +5 more
openalex +1 more source
The Plant Journal, Volume 124, Issue 3, November 2025.SUMMARY Terpenoids, the largest and most structurally diverse class of plant natural products, play essential roles in maize defense and ecological interactions. In this study, we identified and functionally characterized a sesquiterpenoid‐based defense pathway in maize centered on α‐santalenoic acid, a pathogen‐inducible sesquiterpenoid antibiotic ...
Mengxi Wu +7 more
wiley +1 more source
Frontiers in Microbiology, 2023 Antimicrobial resistance has attracted worldwide attention and remains an urgent issue to resolve. Discovery of novel compounds is regarded as one way to circumvent the development of resistance and increase the available treatment options. Gossypol is a
Ruo-Lan Du +5 more
doaj +1 more source
Lactylation in cancer: Advances and opportunities for treatment resistance
Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.Aberrant lactylation plays a crucial role in the development of resistance to chemotherapy, immunotherapy, targeted therapy, and radiotherapy. Strategies to overcome this resistance include the inhibition of key glycolytic enzymes, targeting lactate transporters, synergistic therapeutic approaches, and the inhibition of specific site.
Keke Xu +10 more
wiley +1 more source
GOSSYPOL PROMOTES THE DEGENERATION OF CHICKEN OVARIAN FOLLICLES IN VITRO
Brazilian Journal of Poultry ScienceGossypol, a phenolic compound produced by the pigment glands of cotton, is known to affect male reproduction. In females, exposure to gossypol has been associated with interference with the estrous cycle and embryo development.
ICN Gadelha +3 more
doaj +1 more source