Results 81 to 90 of about 14,116 (259)

Acute toxicity of gossypol in northern bobwhites

Journal of Applied Animal Research, 2019
Gossypol, a secondary metabolite found in cotton (Gossypium spp.), is known to be toxic to a variety of animals, particularly monogastric mammals and commercial poultry (Gallus domesticus).
Amy L. Farthing, Thomas W. Schwertner, David J. Gasper, Heather A. Mathewson, Kimberly A. Guay   +4 more
doaj   +1 more source

The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]

, 2018
Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi, Colapietro, Alessandro, Cristiano, Loredana, Delle Monache, Simona, Festuccia, Claudio, Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mehrling, Thomas, Pompili, Simona, Tombolini, Vincenzo, Vetuschi, Antonella, Vitale, Flora   +12 more
core   +2 more sources

Epithelial–Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications

MedComm, Volume 6, Issue 9, September 2025.
This graphical abstract summarizes the effects of ionizing radiation (IR) on epithelial–mesenchymal transition (EMT), emphasizing critical processes such as DNA damage repair, tumor microenvironment interactions, and resistance mechanisms. It highlights EMT‐induced radioresistance regulators, such as TGF‐β, Wnt, Notch, ERK, and various miRNAs, as well ...
Dhasarathdev Srinivasan, Ranjith Balakrishnan, Ankush Chauhan, Jeevan Kumar, Dinesh Murugan Girija, Reena Shrestha, Rupendra Shrestha, Rajasekaran Subbarayan   +7 more
wiley   +1 more source

Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications

MedComm, Volume 6, Issue 9, September 2025.
NK cells eliminate tumors via cytotoxicity and cytokine secretion. Tumor microenvironment‐driven immunosuppression and metabolic reprogramming subvert NK cells’ cytotoxicity. The current clinical strategies to restore NK activity include ex vivo expansion for adoptive transfer, CAR‐NK engineering, TME‐remodeling agents, immune checkpoint blockade ...
Nanzhi Luo, Cong Chen, Wenjing Zhou, Jianqi Hao, Song He, Yu Liu, Yin Ku, Linhua Huang, Chuanfen Zhang, Yueli Shu, Xiaoqing Wu, Yaojia Zhou, Jian Zhang   +12 more
wiley   +1 more source

Clonal Composition of Human Adrenocortical Neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S., Allolio, B., Beuschlein, Felix, Chrousos, G. P., Jaursch-Hancke, C., Karl, M., Reincke, Martin, Travis, W.   +7 more
core  

Mechanism study of alachlor biodegradation by Paecilomycesmarquandii with proteomic and metabolomic methods [PDF]

, 2015
Alachlor is an herbicide that is widely used worldwide to protect plant crops against broadleaf weedsand annual grasses. However, due to its endocrine-disrupting activity, its application had been bannedin the European Union.
Adrian Soboń, Agrawal, Altschul, Bregar, Böger, Carvalho, Charles, Chen, Chen, Chirnside, Coleman, Doyle, Fava, Feng, Ferreira de Oliveira, Ferrey, Fujii, Hou, Jerzy Długoński, Keum, Kroll, Li, Matsuzaki, Mirosława Słaba, Miura, Munoz, Perkins, Pothuluri, Rafał Szewczyk, Ringnér, Różalska, Salvachúa, Seo, Sette, Stamper, Szewczyk, Słaba, Słaba, Słaba, Tessier, Wei, Yang, Zhang   +42 more
core   +1 more source

Analysis of the Microsporogenis of BC2A and BC3. Plants Issued from the G. hirsutum L. x G. raimondii Ulb. x G. sturtianum Will [PDF]

Tropicultura, 2000
In order to introgress the low-gossypol-seed and high-gossypol-plant trait in the main cultivated cotton species, a BC2 plant issued from the HRS trispecific hybrid [(G. hirsutum x G. raimondiij 2x G. sturtianum/was backcrossed to G.
Sanogo, MD., Vroh Bi, I., Baudoin, JP., Mergeai, G.   +3 more
doaj  

Distribution of Gossypol Glands on Cotton (Gossypium hirsutum L.) Genotypes

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2010
Knowing the distribution of gossypol glands in cotton will help to improve advanced cultivars with great economic return. The aim is to compare cotton genotypes for the number and the distribution of gossypol glands found in different plant parts and to ...
Yuksel BOLEK, Said M. FIDAN, Mustafa OGLAKCI   +2 more
doaj   +1 more source

(−)-Gossypol Inhibits Growth and Promotes Apoptosis of Human Head and Neck Squamous Cell Carcinoma In Vivo

Neoplasia: An International Journal for Oncology Research, 2006
Resistance to chemotherapy is a common problem encountered in the treatment of head and neck squamous cell carcinoma (HNSCC). Chemoresistant HNSCC tumors frequently overexpress antiapoptotic proteins, such as BCI-xL. (−)-Gossypol, the negative enantiomer
Keith G. Wolter, Steven J. Wang, Bradley S. Henson, Shaomeng Wang, Kent A. Griffith, Bhavna Kumar, Jianyong Chen, Thomas E. Carey, Carol R. Bradford, Nisha J. D'Silva   +9 more
doaj   +1 more source

Rhizobacteria prime the activation of plant defense and nutritional responses to suppress aphid populations on barley over time

New Phytologist, Volume 247, Issue 5, Page 2390-2405, September 2025.
Summary Interactions between plants and soil microbes are widespread and are documented to modulate plant–insect herbivore interactions. Still, it remains unclear how these shape the overall plant defense responses and the mechanisms in suppressing insect populations.
Crispus M. Mbaluto, Sharon E. Zytynska
wiley   +1 more source