The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]
, 2018 Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi +12 more
core +2 more sources
Acute toxicity of gossypol in northern bobwhites
Journal of Applied Animal Research, 2019 Gossypol, a secondary metabolite found in cotton (Gossypium spp.), is known to be toxic to a variety of animals, particularly monogastric mammals and commercial poultry (Gallus domesticus).
Amy L. Farthing +4 more
doaj +1 more source
Lactylation in cancer: Advances and opportunities for treatment resistance
Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.Aberrant lactylation plays a crucial role in the development of resistance to chemotherapy, immunotherapy, targeted therapy, and radiotherapy. Strategies to overcome this resistance include the inhibition of key glycolytic enzymes, targeting lactate transporters, synergistic therapeutic approaches, and the inhibition of specific site.
Keke Xu +10 more
wiley +1 more source
Mechanism study of alachlor biodegradation by Paecilomycesmarquandii with proteomic and metabolomic methods [PDF]
, 2015 Alachlor is an herbicide that is widely used worldwide to protect plant crops against broadleaf weedsand annual grasses. However, due to its endocrine-disrupting activity, its application had been bannedin the European Union.
Adrian Soboń +42 more
core +1 more source
Food Safety and Health, Volume 3, Issue 4, Page 668-679, October 2025.trans‐ferulic acid and sinapic acid could be used to distinguish Chinese ginseng from American ginseng. Panax quinquefolius from China and the United States produced unique metabolites and phenolic compounds. ABSTRACT Currently, there is a relative paucity of comparative studies on the metabolites of American ginseng from different geographical sources.
Dan Li +6 more
wiley +1 more source
Le cotonnier sans gossypol, une source de protéines alimentaires. Situation actuelle et perspectives d'avenir, après le colloque d'Abidjan [PDF]
, 1987 Commentaires sur le colloque de novembre 1985 à Abidjan. Conditions de la culture de cotonniers sans glandles, intérêt des dérivés des graines sans gossypol en alimentation des animaux et surtout en alimentation humaine, problèmes économiques et ...
Bourely, Jean
core
Utilisation alimentaire des dérivés des cotonniers sans gossypol [PDF]
, 1987 Le procédé industriel classique d'extraction de l'huile est rappelé. Une technologie améliorée d'extraction directe par solvant permet d'obtenir une farine utilisable en alimentation humaine.
Marquié, Catherine
core
Change in Nutritional Quality of Detached Aspen and Willow Foliage Used as Insect Food in the Laboratory [PDF]
, 2017 Leaves of Populus tremuloides and Salix babylonica held in the laboratory as for feeding insects were analyzed for total nitrogen, total phenolics, and total sugars at 0, 3, and 6 days.
Miller, William E
core +3 more sources
Analysis of the Microsporogenis of BC2A and BC3. Plants Issued from the G. hirsutum L. x G. raimondii Ulb. x G. sturtianum Will [PDF]
Tropicultura, 2000 In order to introgress the low-gossypol-seed and high-gossypol-plant trait in the main cultivated cotton species, a BC2 plant issued from the HRS trispecific hybrid [(G. hirsutum x G. raimondiij 2x G. sturtianum/was backcrossed to G.
Sanogo, MD. +3 more
doaj
Neoplasia: An International Journal for Oncology Research, 2006 Resistance to chemotherapy is a common problem encountered in the treatment of head and neck squamous cell carcinoma (HNSCC). Chemoresistant HNSCC tumors frequently overexpress antiapoptotic proteins, such as BCI-xL. (−)-Gossypol, the negative enantiomer
Keith G. Wolter +9 more
doaj +1 more source