Results 41 to 50 of about 543,714 (293)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Annals of Global Health, 2017 This poem is based on panel discussions and a quote from a paper by Dr. Sandra Gray presented at the 115th American Anthropological Association’s meetings in Minneapolis, titled “‘My Mother Got Annoyed’: Ethnographic Discourse and Narratives of Suicide ...
Casey Golomski
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
EDIS, 2009 FOR-223, a 2-page fact sheet by Benjamin Koubek and Chris Demers, describes the FloridaInvasives.org website and how it can help landowners and land managers locate valuable technical and financial assistance programs to prevent or control invasive ...
Benjamin Koubek, Chris Demers
doaj +5 more sources
'They've got their backs to the sea': Careers Work in Kent's coastal schools [PDF]
, 2016 Kent's coastal schools are a highly diverse group of institutions which serve a range of different communities. In a literal sense the young people of Kent have got their backs to the sea.
Shepherd, Claire, Hooley, Tristram
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
De rerum naturalium principiis
quas ... praeside ... Ioh. Rodolpho Gigero ... publicè defendendas suscipit Ionas Le Gotius Neocomensis, ad diem 3. Martii 1653, horis & loco solitisJonas Le Got ist Autor der DissertationDiss.
Le Got, Jonas
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source