Results 201 to 210 of about 78,942 (265)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1889-1899, December 2025.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima   +5 more
wiley   +1 more source

A novel surgical approach for carpal tunnel syndrome caused by tophi

open access: yesAsian Journal of Surgery
Chaoqun Ma   +3 more
doaj   +1 more source

3D Body Scanning–Derived Normative Values of Appendicular Circumferences: A Novel Tool for Sarcopenia Screening in Chinese Adults

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Appendicular circumferences (ACs) are critical predictors of skeletal health, cardiovascular disease risk and mortality. Currently, comprehensive reference values and associated factors for thigh (TC), calf (CC), upper arm (UAC) and forearm (FC) circumferences remain unestablished in Chinese adults.
Huijing He   +15 more
wiley   +1 more source

Characterizing Microstructural and Mechanical Properties of Dancer Achilles Tendon Using Ultrashort Echo Time MRI and Shear Wave Elastography Ultrasound

open access: yesJournal of Orthopaedic Research, Volume 43, Issue 12, Page 2093-2101, December 2025.
ABSTRACT Previous observations of multi‐echo ultrashort echo time (UTE) magnetic resonance imaging (MRI) decay data from the Achilles tendon (AT) report an off‐resonance non‐water signal associated with non‐collagenous extracellular matrix (ECM) constituents.
Anna M. Horner   +10 more
wiley   +1 more source

A case of gout with glycogen storage disease type Ia

open access: green, 2002
Hyun‐Kuk Kim   +6 more
openalex   +1 more source

A clinical case of a patient with gout complicated by chronic osteomyelitis

open access: hybrid
B.A. Lekomtsev   +4 more
openalex   +2 more sources

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

open access: yesMedComm, Volume 6, Issue 12, December 2025.
E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Haochen Wang   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy