Results 191 to 200 of about 64,826 (258)

Therapeutic Strategies for Hyperuricemia: From Small-Molecule Inhibitors to RNA Therapeutics. [PDF]

ACS Pharmacol Transl Sci
Yu X, Zhang M, Huang Y.
europepmc   +1 more source

Potent and Sustained Lowering of Serum Uric Acid by YJH‐012‐D, a GalNAc‐Conjugated siRNA Targeting Xanthine Dehydrogenase

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
We developed a GalNAc‐conjugated siRNA targeting hepatic XDH, which effectively reduces uric acid production by silencing XDH expression, offering a promising therapeutic approach for hyperuricemia. ABSTRACT Hyperuricemia (HUA) is primarily driven by hepatic overproduction of urate, mediated by xanthine dehydrogenase (XDH).
Tingke Tang, Qiuying Li, Chenguang Zhang, Yongxing Wang, Lu Yang, Haibin Huang, Yujun He, Zhi Zheng, Dong Liang, Meng Wang, Yingyu Wu, Chengjiang Zhao, Wenhao Cui   +12 more
wiley   +1 more source

Incidence of gout in spondyloarthritis. [PDF]

Rheumatol Adv Pract
Johnston S, Zuckerman B, Sharma A, Alam U, Zhao SS.   +4 more
europepmc   +1 more source

Upper Urinary Tract Stone Disease: Practical Guidance for Early Assessment and Management

Trends in Urology &Men's Health, Volume 17, Issue 4, August 2026.
ABSTRACT Upper urinary tract stone disease is a common urological condition with high recurrence rates and a significant healthcare burden. Many patients initially present in community or primary care settings, where early assessment and triage influence patient safety, referral timing and subsequent urological management.
Matthew Kwon, Avi Raman
wiley   +1 more source

Severe Tophaceous Gout After Decades of Progressive Disease: A Case Report. [PDF]

Cureus
Weiderman G, Jianu NC, Karastury S, Mann P, Lorenz N, Jianu A, Walsh D.   +6 more
europepmc   +1 more source

Lunar Trailblazer Spacecraft Tracking and Mission Recovery Attempt: Characterization of Status and Behavior of a Non‐Cooperative Object in Cis‐Lunar Space

Earth and Space Science, Volume 13, Issue 8, August 2026.
Abstract Unexpectedly following launch, the Lunar Trailblazer mission experienced software anomalies that led it to orient solar panels away from the sun and lose communication with Earth. This paper describes efforts to determine the spacecraft state and attempt recovery of the mission's science at the Moon.
B. L. Ehlmann, J. Bellerose, G. Lantoine, E. Furlan, E. Scire, S. Fajardo‐Acosta, L. Bennett, M. Sanchez Net, T. J. W. Lazio, M. Brozović, J. Masiero, A. V. Steckel, P. A. Burke, M. Kimura, S. Foxman, M. P. M. Zaw, L. M. Lee, F. Clarke, M. Hauge, D. McDonald, J. Adler, R. Strauss, D. Trilling, C. S. Edwards, M. C. Nolan, D. Lyster, L. Robinson, A. T. Klesh, C. C. Seybold   +28 more
wiley   +1 more source

Elevated serum cystatin C predicts tophus formation in gout: evidence from a cross-sectional study. [PDF]

Front Endocrinol (Lausanne)
Hu Y, Li C, Liu T, Lu J, Ji A, Wang Y, Dong B.   +6 more
europepmc   +1 more source

Enriching historical biologging datasets on seabirds using deep neural networks: A transformer‐based approach to infer energy expenditure proxy from GPS and environmental data

Methods in Ecology and Evolution, Volume 17, Issue 8, Page 2408-2423, August 2026.
Abstract Recent advances in biologging have led to the widespread use of accelerometers, which generate high‐resolution movement data essential for understanding animal behaviour. Derived from tri‐axial accelerometry, Overall Dynamic Body Acceleration (ODBA) serves as a proxy for energy expenditure that is less invasive and more cost‐effective than ...
Noémie Muquet, Adrien Brunel, Christophe Barbraud, Leandro Bugoni, Karine Delord, Guilherme Tavares Nunes, Jean‐Daniel Zucker, Sophie Lanco   +7 more
wiley   +1 more source

Utility of large language models as information tools for nursing care in gout: a comparative study of DeepSeek and ChatGPT. [PDF]

Front Med (Lausanne)
Pan X, Wang Y, Yang Q, Wang J, Tong Y, Zhang D, Lv X, Zheng C, Wu M, Li T, Tang L, Huang Z.   +11 more
europepmc   +1 more source

Construction and Validation of Plasma Protein‐Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles

Aging Cell, Volume 25, Issue 8, August 2026.
We developed plasma protein‐based musculoskeletal aging clocks, MSKAge and MSKAgeMort, using UK Biobank proteomic data, and showed that MSKAgeAccel and MSKAgeMortAccel (in particular) predicted mortality, musculoskeletal disorders, and age‐related diseases effectively.
Yangdan Zhong, Maoyao Xia, Xunying Zhao, Yang Qu, Bowen Lei, Sirui Zhen, Tao Han, Rong Xiang, Jinyu Xiao, Xin Song, Xiaofeng Ma, Bin Yang, Di Zhang, Jinyu Zhou, Zilan Chen, Yuqi Pang, Ye Ju, Ting Liu, Zihao Li, Lu Long, Tao Zhang, Jiayuan Li, Mengyu Fan, Zuyun Liu, Xia Jiang   +24 more
wiley   +1 more source