Results 251 to 260 of about 174,736 (301)

Frailty as a Key Determinant of Cardiovascular Risk and Mortality in Preserved Ratio Impaired Spirometry: A Nationally Representative Study

open access: yesThe Clinical Respiratory Journal, Volume 20, Issue 1, January 2026.
In adults with preserved ratio impaired spirometry (PRISm), frailty was common and strongly associated with increased cardiovascular events and all‐cause mortality. Frailty significantly improved risk stratification beyond traditional clinical factors. A frailty‐based nomogram demonstrated good discrimination and calibration, highlighting frailty as a ...
Yue Ren   +5 more
wiley   +1 more source

Partial non‐adherence to antidiabetic therapy undermines diabetes management and correlates with treatment complexity: A cross‐sectional study using blood plasma analysis

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 186-196, January 2026.
Abstract Aims To evaluate medication adherence in patients with type 2 diabetes (T2D) using plasma drug measurements and assess the clinical impact of partial non‐adherence on glycemic control and complications. Materials and Methods This cross‐sectional study included 641 T2D outpatients attending routine follow‐up visits.
Vojtěch Škop   +9 more
wiley   +1 more source

Lobeglitazone improves glycaemic control as add‐on therapy to empagliflozin plus metformin in patients with type 2 diabetes mellitus: A double‐blind, randomised, placebo‐controlled trial

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 728-740, January 2026.
Abstract Aims This study aimed to evaluate the efficacy and safety of triple therapy with lobeglitazone 0.5 mg as an add‐on treatment compared with placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and empagliflozin.
Da Hea Seo   +8 more
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

open access: yesGeriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi   +4 more
wiley   +1 more source

The Immunological Consequences of Clonal Hematopoiesis in Heart Failure

open access: yesImmunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Inflammation is increasingly recognized as a central driver of heart failure (HF), particularly in older adults, yet the underlying immune mechanisms remain diverse and incompletely understood. Clonal hematopoiesis (CH), defined by the expansion of somatically mutated hematopoietic clones, has emerged as a risk factor for the development of ...
Megan A. Evans, Kenneth Walsh
wiley   +1 more source

Metabolic dysfunction-associated fatty liver disease and the risk of gout: a UK Biobank prospective cohort study. [PDF]

open access: yesEur J Med Res
Liu X   +9 more
europepmc   +1 more source

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