Results 61 to 70 of about 216,147 (379)

Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator

open access: yesAnnals of Thoracic Medicine, 2012
The CFTR gene is unique within the ATP-binding cassette (ABC) protein family, predominantly of transporters, by coding a chloride channel. The gating mechanism of ABC proteins has been characterized by the ATP Switch model in terms cycles of dimer ...
Taras Gout
doaj   +1 more source

Systematic review and quality analysis of emerging diagnostic measures for calcium pyrophosphate crystal deposition disease. [PDF]

open access: yes, 2016
ObjectivesCalcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR ...
Chen, K, Terkeltaub, R, Wu, Y
core   +1 more source

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

open access: yesInternational Journal of Molecular Sciences, 2021
Urate homeostasis in humans is a complex and highly heritable process that involves i.e., metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate excretion.
Robert Eckenstaler, R. Benndorf
semanticscholar   +1 more source

Effects of Non‐Aspirin Nonsteroidal Anti‐Inflammatory Drugs on Acute Intracerebral Hemorrhage

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite celecoxib, a cyclooxygenase‐2 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation‐mediated perihematomal edema in rat models, the evidence of its effects on patient outcomes remains limited.
Shin‐Joe Yeh   +3 more
wiley   +1 more source

Natural Changbai mineral water reduces obesity risk through regulating metabolism and gut microbiome in a hyperuricemia male mouse model

open access: yesFrontiers in Nutrition
Access to clean and safe drinking water is essential. This study aimed to evaluate the effect of a kind of small molecular natural mineral water, C-cell mineral water on hyperuricemia male mice metabolism condition.
Maichao Li   +26 more
doaj   +1 more source

CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

open access: yesCell Reports, 2023
Summary: Adipose-derived stem cells (ASCs) drive healthy visceral adipose tissue (VAT) expansion via adipocyte hyperplasia. Obesity induces ASC senescence that causes VAT dysfunction and metabolic disorders.
Zixin Zhou   +16 more
doaj   +1 more source

Impact of gout on the risk of atrial fibrillation [PDF]

open access: yes, 2016
OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF ...
Chang-Fu Kuo   +7 more
core   +1 more source

2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout

open access: yesAnnals of the Rheumatic Diseases, 2019
Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed. New data on imaging and clinical diagnosis have become available since the first EULAR recommendations for the diagnosis of gout in 2006.
P. Richette   +23 more
semanticscholar   +1 more source

Time Trends and Predictors of Gout Remission Over 6 Years

open access: yesArthritis Care &Research, EarlyView.
Objective This study aims to describe the trends in remission rates over 6 years of follow‐up among people with gout taking urate‐lowering therapy (ULT) and to identify variables that predict remission. Methods A post hoc analysis was conducted using data from the Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES) trial ...
Adwoa Dansoa Tabi‐Amponsah   +5 more
wiley   +1 more source

The Patient Experience of Gout Remission: A Qualitative Study

open access: yesACR Open Rheumatology, 2023
Objective Preliminary remission criteria for gout have been developed. However, the patient experience of gout remission has not been described. This qualitative study aimed to understand the patient experience of gout remission and views about the ...
Adwoa Dansoa Tabi‐Amponsah   +4 more
doaj   +1 more source

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