Results 61 to 70 of about 78,942 (265)

Association of urine autoantibodies with disease activity in systemic lupus erythematosus

Frontiers in Medicine
ObjectiveThe presence of urinary autoantibodies in patients with systemic lupus erythematosus (SLE) has been confirmed by several studies; however, the significance of their presence in urine remains unclear.
Yuxian Zhang, Yuxian Zhang, Xiaoxia Qu, Xiaoxia Qu, Lishui Wang, Lijun Song, Lijun Song   +6 more
doaj   +1 more source

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

Annals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Kitti Thiankhaw, Rupert Oliver, Victoria Harvey, Gareth Ambler, Michael Zandi, Hans Rolf Jäger, David J. Werring   +9 more
wiley   +1 more source

Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential

, 2021
Mengze Zhou, Weiwei Wang, Zhongkui Wang, Yilin Wang, Yifan Zhu, Zhiqian Lin, Sheng Tian, Yuan Huang, Qinghua Hu, Huanqiu Li   +9 more
openalex   +1 more source

Staff perspectives on existing practice and conditions for nurse-led gout care based on treatment recommendations: a qualitative study in primary health care [PDF]

, 2021
Helene Sedelius, Malin Tistad, Ulrika Bergsten, Mats Dehlin, David Iggman, Lars Wallin, Anna Svärd   +6 more
openalex   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

Frontiers in Pharmacology
BackgroundInterleukin-6 (IL-6) is a pleiotropic cytokine, with specific effects depending on the immune microenvironment. Extensive research has confirmed the pathological roles of the IL-6/JAK2/STAT1/3 signaling pathway in inflammation, autoimmunity ...
Zeng Zhang, Zeng Zhang, Zeng Zhang, Zeng Zhang, Peng Wang, Peng Wang, Tianyi Lei, Tianyi Lei, Jianwei Guo, Jianwei Guo, Yi Jiang, Yi Jiang, Yanhui Li, Yanhui Li, Jianxiong Zheng, Jianxiong Zheng, Shunbing Wang, Shunbing Wang, Haimuzi Xu, Haimuzi Xu, Guilin Jian, Guilin Jian, Quanbo Zhang, Quanbo Zhang, Quanbo Zhang, Yufeng Qing, Yufeng Qing, Yufeng Qing   +27 more
doaj   +1 more source

Risk of gout flares after COVID-19 vaccination: A case-crossover study

, 2022
Hui Li, Nicola Dalbeth, Zachary S. Wallace, Jeffrey A. Sparks, Xiaoxiao Li, Chao Zeng, Yilun Wang, Dongxing Xie, Guanghua Lei, Jie Wei, Yuqing Zhang   +10 more
openalex   +2 more sources

Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double‐Blind, Phase 3 Trial in China

Arthritis &Rheumatology, EarlyView.
Objective Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicenter, randomized, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad ...
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Hyperuricaemia and Gout: A Review

South African Family Practice, 2010
Gout is a painful, inflammatory disease that affects more men than women. The incidence of gout has increased substantially over the past few decades, as evidenced by information from the Rochester project. Some of the risk factors for the development of
Amy Kopke, Oppel B.W. Greeff
doaj   +1 more source

Clinical Impact of Multiparametric Contrast‐Enhanced Dual‐Energy Computed Tomography in Arthritis Imaging: A Prospective Single‐Center Study

Arthritis &Rheumatology, EarlyView.
Objective We aimed to evaluate the influence of contrast‐enhanced dual‐energy computed tomography (CE‐DECT) in detecting and differentiating rheumatic joint diseases of the hand. Methods In this prospective study, patients with suspected arthritis of the hand were investigated consecutively alongside the standard clinical procedure.
Sevtap Tugce Ulas, Jürgen Mews, Sarah Ohrndorf, Robert Biesen, Katharina Ziegeler, Edgar Wiebe, Fabian Proft, Udo Schneider, Denis Poddubnyy, Torsten Diekhoff   +9 more
wiley   +1 more source