Results 41 to 50 of about 89,794 (164)

A machine learning-assisted model for renal urate underexcretion with genetic and clinical variables among Chinese men with gout

Arthritis Research & Therapy, 2022
Objectives The objective of this study was to develop and validate a prediction model for renal urate underexcretion (RUE) in male gout patients. Methods Men with gout enrolled from multicenter cohorts in China were analyzed as the development and ...
Mingshu Sun, Wenyan Sun, Xuetong Zhao, Zhiqiang Li, Nicola Dalbeth, Aichang Ji, Yuwei He, Hongzhu Qu, Guangmin Zheng, Lidan Ma, Jiayi Wang, Yongyong Shi, Xiangdong Fang, Haibing Chen, Tony R. Merriman, Changgui Li   +15 more
doaj   +1 more source

Gout? apa yang orang awam perlu tahu? [PDF]

, 2021
Gout adalah penyakit yang telah berada sekian lama dengan kita yang dipanggil ‘ancient disease’ dan telah di perkenalkan oleh Hippocrates pada abad ke 5.
Che' Man, Mohamad, Che Alhadi, Shahidah
core  

Global, regional, and national burden of gout, 1990-2020, and projections to 2050 : a systematic analysis of the Global Burden of Disease Study 2021 [PDF]

BACKGROUND: Gout is an inflammatory arthritis manifesting as acute episodes of severe joint pain and swelling, which can progress to chronic tophaceous or chronic erosive gout, or both.
GBD 2021 Gout Collaborators
core   +3 more sources

Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator

Annals of Thoracic Medicine, 2012
The CFTR gene is unique within the ATP-binding cassette (ABC) protein family, predominantly of transporters, by coding a chloride channel. The gating mechanism of ABC proteins has been characterized by the ATP Switch model in terms cycles of dimer ...
Taras Gout
doaj   +1 more source

Articulation de deux approches, holiste et analytique, pour étudier le parcours professionnel de l’entrepreneur dirigeant d’entreprise

Éducation et Socialisation, 2021
Entrepreneurship is a sought-after research topic and the fields of education and skill training are no exception. However, the latest models of the entrepreneurial process agree on the complexity of this research topic.
Varvara Ciobanu-Gout
doaj   +1 more source

Amplicon targeted resequencing for SLC2A9 and SLC22A12 identified novel mutations in hypouricemia subjects

Molecular Genetics & Genomic Medicine, 2019
Background To identify potential causative mutations in SLC2A9 and SLC22A12 that lead to hypouricemia or hyperuricemia (HUA). Methods Targeted resequencing of whole exon regions of SLC2A9 and SLC22A12 was performed in three cohorts of 31 hypouricemia ...
Zhaowei Zhou, Ke Wang, Juan Zhou, Can Wang, Xinde Li, Lingling Cui, Lin Han, Zhen Liu, Wei Ren, Xuefeng Wang, Keke Zhang, Zhiqiang Li, Dun Pan, Changgui Li, Yongyong Shi   +14 more
doaj   +1 more source

Advanced pharmacological treatment in Gout

, 2020
Gout is a systemic disease that results from the deposition of monosodium urate crystals in tissues. Increased serum uric acid above a specific threshold is a requirement for the formation of uric acid crystals. The central cause of gout is deposition of
Kim, Minho
core  

Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila

Scientific Reports
Artificial sweeteners are highly sweet, non-nutritive compounds that have become increasingly popular over recent decades despite research suggesting that their consumption has unintended consequences. Specifically, there is evidence suggesting that some
Christian Arntsen, Jake Grenon, Isabelle Chauvel, Stéphane Fraichard, Stéphane Dupas, Jérôme Cortot, Kayla Audette, Pierre-Yves Musso, Molly Stanley   +8 more
doaj   +1 more source

DUSP1 Mitigates MSU-Induced Immune Response in Gouty Arthritis Reinforcing Autophagy

Frontiers in Bioscience-Landmark
Background: Persistent hyperuricemia can lead to the generation and deposition of monosodium urate (MSU) crystals. This can trigger gouty arthritis (GA), which in turn induces inflammation.
Jing Nie, Hongbin Qiu
doaj   +1 more source

The Patient Experience of Gout Remission: A Qualitative Study

ACR Open Rheumatology, 2023
Objective Preliminary remission criteria for gout have been developed. However, the patient experience of gout remission has not been described. This qualitative study aimed to understand the patient experience of gout remission and views about the ...
Adwoa Dansoa Tabi‐Amponsah, Sarah Stewart, Graham Hosie, Anne Horne, Nicola Dalbeth   +4 more
doaj   +1 more source