Results 21 to 30 of about 89,794 (164)

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

Frontiers in Pharmacology, 2021
Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders.
Quan-Bo Zhang, Quan-Bo Zhang, Dan Zhu, Dan Zhu, Dan Zhu, Fei Dai, Fei Dai, Yu-Qin Huang, Yu-Qin Huang, Jian-Xiong Zheng, Jian-Xiong Zheng, Yi-Ping Tang, Yi-Ping Tang, Zeng-Rong Dong, Zeng-Rong Dong, Xia Liao, Xia Liao, Yu-Feng Qing, Yu-Feng Qing   +18 more
doaj   +1 more source

The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study [PDF]

, 2019
ObjectiveObstructive sleep apnea (OSA) is associated with a range of serious comorbidities. This study investigates whether people with OSA are more likely to develop gout than those without OSA in both short and long term.Methods A matched retrospective
Christian Mallen, Sophie West, Roddy, Edward, Edward Roddy, Richard Hayward, Mallen, Christian, Sara Muller, Muller, Sara, Blagojevic‐Bucknall, Milica, Milica Blagojevic‐Bucknall, Hayward, Richard, Choi, Hyon, West, Sophie, Hyon Choi   +13 more
core   +1 more source

Identification of a Novel Mutation in a Pseudohypoparathyroidism Family

International Journal of Endocrinology, 2011
Pseudohypoparathyroidism type Ia (PHP Ia) is defined as a series of disorders characterized by multihormone resistance in end-organs and Albright hereditary osteodystrophy (AHO) phenotype.
Zhi-Min Miao, Can Wang, Bin-Bin Wang, Dong-Mei Meng, Dong-Mei Su, Zhi Cheng, Qiao-Lian Wen, Lin Han, Qing Yu, Xu Ma, Chang-Gui Li   +10 more
doaj   +1 more source

Food oral processing in humans: links between physiological parameters, release of flavour stimuli and flavour perception of food

International Journal of Food Studies, 2018
In humans, food oral processing (FOP) is the first step in the digestive process. It prepares the food for swallowing and to undergo the process of digestion.
Gilles Feron, Christian Salles
doaj   +1 more source

The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

Oncogenesis, 2022
Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). However, the regulatory
Xiaomin Ma, Xiaoxiao Ma, Lihui Zhu, Yunxue Zhao, Mengmeng Chen, Tao Li, Yueke Lin, Dapeng Ma, Caiyu Sun, Lihui Han   +9 more
doaj   +1 more source

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank [PDF]

, 2021
Objectives: To perform a genome-wide association study (GWAS) of gout cases vs. asymptomatic hyperuricaemia (AH) controls, and gout cases vs. normouricaemia controls, and to generate a polygenic risk score (PRS) to determine gout-case vs.
Sandoval-Plata, Gabriela, Abhishek, Abhishek, Morgan, Kevin   +2 more
core   +1 more source

The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective Controlled Cohort Study

Frontiers in Medicine, 2022
ObjectiveInterstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD) that manifests as several subtypes with significant differences in prognosis.
Jiaqi Wang, Jiaqi Wang, Xiao Wang, Xiao Wang, Xiaoyan Qi, Xiaoyan Qi, Zhijian Sun, Zhijian Sun, Tao Zhang, Yi Cui, Qiang Shu, Qiang Shu   +11 more
doaj   +1 more source

Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese

Hereditas, 2019
Background Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, SLC28A2, exerts susceptibility for SUA fluctuation and incidence of HUA and gout in
Zhaowei Zhou, Zhiqiang Li, Can Wang, Xinde Li, Xiaoyu Cheng, Changgui Li, Yongyong Shi   +6 more
doaj   +1 more source

Understanding and perceptions of gout: an interdisciplinary assessment among patients, physicians and pharmacists in Italy

Reumatismo, 2020
The objective was to assess knowledge and therapeutic approaches to the management of gout among healthcare professionals and people with/without gout, in Italy.
L. Punzi, G. Medea
doaj   +1 more source

IL-37 isoform D acts as an inhibitor of soluble ST2 to boost type 2 immune homeostasis in white adipose tissue

Cell Death Discovery, 2022
White adipose tissue (WAT) homeostasis substantiated by type 2 immunity is indispensable to counteract obesity and metabolic disorders. IL-33/suppression of tumorigenicity (ST) 2 signaling promotes type 2 response in WAT, while potential regulators ...
Chaoze Li, Mingsheng Zhao, Ming Zhao, Nuo Chen, Yaxin Guo, Yingxin Du, Yi Zhang, Baihui Cao, Bing Zhan, Chun Guo, Yuan Li, Yan Li, Yongyu Shi, Faliang Zhu, Lining Zhang, Qun Wang   +15 more
doaj   +1 more source