Results 31 to 40 of about 177,759 (342)

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

open access: yesFrontiers in Pharmacology, 2021
Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders.
Quan-Bo Zhang   +18 more
doaj   +1 more source

Two-Page Book Embeddings of 4-Planar Graphs [PDF]

open access: yes, 2014
Back in the Eighties, Heath showed that every 3-planar graph is subhamiltonian and asked whether this result can be extended to a class of graphs of degree greater than three.
Bekos, Michael A.   +2 more
core   +2 more sources

Identification of a Novel Mutation in a Pseudohypoparathyroidism Family

open access: yesInternational Journal of Endocrinology, 2011
Pseudohypoparathyroidism type Ia (PHP Ia) is defined as a series of disorders characterized by multihormone resistance in end-organs and Albright hereditary osteodystrophy (AHO) phenotype.
Zhi-Min Miao   +10 more
doaj   +1 more source

Food oral processing in humans: links between physiological parameters, release of flavour stimuli and flavour perception of food

open access: yesInternational Journal of Food Studies, 2018
In humans, food oral processing (FOP) is the first step in the digestive process. It prepares the food for swallowing and to undergo the process of digestion.
Gilles Feron, Christian Salles
doaj   +1 more source

Unstable and Stable Galaxy Models [PDF]

open access: yes, 2007
To determine the stability and instability of a given steady galaxy configuration is one of the fundamental problems in the Vlasov theory for galaxy dynamics. In this article, we study the stability of isotropic spherical symmetric galaxy models $f_{0}(E)
Guo, Yan, Lin, Zhiwu
core   +1 more source

The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

open access: yesOncogenesis, 2022
Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). However, the regulatory
Xiaomin Ma   +9 more
doaj   +1 more source

The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective Controlled Cohort Study

open access: yesFrontiers in Medicine, 2022
ObjectiveInterstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD) that manifests as several subtypes with significant differences in prognosis.
Jiaqi Wang   +11 more
doaj   +1 more source

Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese

open access: yesHereditas, 2019
Background Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, SLC28A2, exerts susceptibility for SUA fluctuation and incidence of HUA and gout in
Zhaowei Zhou   +6 more
doaj   +1 more source

IL-37 isoform D acts as an inhibitor of soluble ST2 to boost type 2 immune homeostasis in white adipose tissue

open access: yesCell Death Discovery, 2022
White adipose tissue (WAT) homeostasis substantiated by type 2 immunity is indispensable to counteract obesity and metabolic disorders. IL-33/suppression of tumorigenicity (ST) 2 signaling promotes type 2 response in WAT, while potential regulators ...
Chaoze Li   +15 more
doaj   +1 more source

An evaluation of seasonal variations in footwear worn by adults with inflammatory arthritis: a cross-sectional observational study using a web-based survey [PDF]

open access: yes, 2014
Background: Foot problems are common in adults with inflammatory arthritis and therapeutic footwear can be effective in managing arthritic foot problems. Accessing appropriate footwear has been identified as a major barrier, resulting in poor adherence
A Brenton-Rule   +42 more
core   +3 more sources

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