Results 61 to 70 of about 81,484 (272)

The Patient Experience of Gout Remission: A Qualitative Study

ACR Open Rheumatology, 2023
Objective Preliminary remission criteria for gout have been developed. However, the patient experience of gout remission has not been described. This qualitative study aimed to understand the patient experience of gout remission and views about the ...
Adwoa Dansoa Tabi‐Amponsah, Sarah Stewart, Graham Hosie, Anne Horne, Nicola Dalbeth   +4 more
doaj   +1 more source

Advanced pharmacological treatment in Gout

, 2020
Gout is a systemic disease that results from the deposition of monosodium urate crystals in tissues. Increased serum uric acid above a specific threshold is a requirement for the formation of uric acid crystals. The central cause of gout is deposition of
Kim, Minho
core  

Gout treatment-helpful treatment options

, 2019
Gout is a relatively common condition affecting those as young as those in their 20’s. There are many risk factors. This case report looks at a 40 years old man who had many acute gout attacks and what treatment options were helpful for ...
Devaraj, Navin Kumar
core   +1 more source

Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies [PDF]

, 2015
ntroductionTo determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis.MethodsSystematic review and meta-analysis of ...
Mallen, Roddy, Belcher
core   +1 more source

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank

, 2021
Objectives: To perform a genome-wide association study (GWAS) of gout cases vs. asymptomatic hyperuricaemia (AH) controls, and gout cases vs. normouricaemia controls, and to generate a polygenic risk score (PRS) to determine gout-case vs.
Sandoval-Plata, Gabriela, Abhishek, Abhishek, Morgan, Kevin   +2 more
core   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila

Scientific Reports
Artificial sweeteners are highly sweet, non-nutritive compounds that have become increasingly popular over recent decades despite research suggesting that their consumption has unintended consequences. Specifically, there is evidence suggesting that some
Christian Arntsen, Jake Grenon, Isabelle Chauvel, Stéphane Fraichard, Stéphane Dupas, Jérôme Cortot, Kayla Audette, Pierre-Yves Musso, Molly Stanley   +8 more
doaj   +1 more source

DUSP1 Mitigates MSU-Induced Immune Response in Gouty Arthritis Reinforcing Autophagy

Frontiers in Bioscience-Landmark
Background: Persistent hyperuricemia can lead to the generation and deposition of monosodium urate (MSU) crystals. This can trigger gouty arthritis (GA), which in turn induces inflammation.
Jing Nie, Hongbin Qiu
doaj   +1 more source

Metabolomic analysis for asymptomatic hyperuricemia and gout based on a combination of dried blood spot sampling and mass spectrometry technology

Journal of Orthopaedic Surgery and Research, 2023
Background Gout is the most common inflammatory arthritis and closely related to metabolic syndrome, leading to excruciating pain and the decline in quality of patients’ life.
Shanshan Liu, Yongting Liu, Xue Wu, Zhengqi Liu   +3 more
doaj   +1 more source