Results 71 to 80 of about 216,147 (379)

The Role of Advanced Imaging in Gout Management

Frontiers in Immunology, 2022
Gout is a common form of inflammatory arthritis where urate crystals deposit in joints and surrounding tissues. With the high prevalence of gout, the standardized and effective treatment of gout is very important, but the long-term treatment effect of ...
Shuangshuang Li, Guanhua Xu, Junyu Liang, Liyan Wan, Heng Cao, Jin Lin   +5 more
doaj   +1 more source

Gout Storm

American Journal of Case Reports, 2021
BACKGROUND Gout is a chronic disease characterized by deposition of monosodium urate crystals, typically manifesting as arthritis. Clinical presentation of gout usually results from activation of local inflammatory response. Despite being one of the oldest diseases in the world, gout pathophysiology is incompletely understood and clinical features are ...
Martins, Danilo, Tonon, Carolina Rodrigues, Pacca, Rafael Lopes, Matchil, Natanye Lemes, Junior, Luiz Antonio Jorge, Queiroz, Dênis Silva, Pereira, Filipe Welson Leal, Silva, Alana Maia, Padovese, Vinicius, De Toledo Moraes, Marcelo Padovani, Da Silva, Daniel Luiz, Nóbrega, Vinicius Cardoso, Curcelli, Emilio Carlos, Okoshi, Marina Politi   +13 more
openaire   +4 more sources

Improvements in Health‐Related Quality of Life with Treat‐to‐Target Urate‐Lowering Therapy in Gout: A Post‐hoc Analysis of a Randomized Multicenter Trial

Arthritis Care &Research, Accepted Article.
Background While treat‐to‐target urate‐lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health‐related quality of life (HRQoL). We assessed the impact of treat‐to‐target ULT on HRQoL among participants receiving protocolized gout care, identifying factors associated with HRQoL and HRQoL change.
Austin Barry, Bryant R. England, Harlan Sayles, Lindsay N. Helget, Maria Androsenko, Hongsheng Wu, Kaleb Michaud, Bridget Kramer, Jeff A. Newcomb, Mary T. Brophy, Anne Davis‐Karim, Ryan Ferguson, Michael H. Pillinger, Tuhina Neogi, Paul M. Palevsky, James R. O'Dell, Ted R. Mikuls   +16 more
wiley   +1 more source

Amplicon targeted resequencing for SLC2A9 and SLC22A12 identified novel mutations in hypouricemia subjects

Molecular Genetics & Genomic Medicine, 2019
Background To identify potential causative mutations in SLC2A9 and SLC22A12 that lead to hypouricemia or hyperuricemia (HUA). Methods Targeted resequencing of whole exon regions of SLC2A9 and SLC22A12 was performed in three cohorts of 31 hypouricemia ...
Zhaowei Zhou, Ke Wang, Juan Zhou, Can Wang, Xinde Li, Lingling Cui, Lin Han, Zhen Liu, Wei Ren, Xuefeng Wang, Keke Zhang, Zhiqiang Li, Dun Pan, Changgui Li, Yongyong Shi   +14 more
doaj   +1 more source

Metabolomic analysis for asymptomatic hyperuricemia and gout based on a combination of dried blood spot sampling and mass spectrometry technology

Journal of Orthopaedic Surgery and Research, 2023
Background Gout is the most common inflammatory arthritis and closely related to metabolic syndrome, leading to excruciating pain and the decline in quality of patients’ life.
Shanshan Liu, Yongting Liu, Xue Wu, Zhengqi Liu   +3 more
doaj   +1 more source

Patients Prescribed Anakinra for Acute Gout Have Baseline Increased Burden of Hyperuricemia, Tophi, and Comorbidities, and Ultimate All-Cause Mortality. [PDF]

, 2019
Objective:The interleukin-1 (IL-1) receptor antagonist anakinra is an effective, off-label option in acute gout flares, when conventional therapy options are narrowed.
Pedersen, Brian, Sharma, Ena, Terkeltaub, Robert   +2 more
core  

Comorbidities in patients with gout prior to and following diagnosis: case-control study [PDF]

, 2016
OBJECTIVES: To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis. METHODS: There were 39 111 patients with incident gout and 39 111 matched controls identified from ...
Ab. Usbott, Abbott, Ames, Annemans, Bhole, Boffetta, Bowman, Cea Soriano, Chang-Fu Kuo, Charlson, Chen, Chhana, Choi, Choi, Choi, Christian Mallen, Clarson, Creighton, De Vera, Deyo, Durward, Erickson, Feinstein, Herrett, Jick, Jick, Jordan, Kanellis, Kellgren, Khan, Khan, Khanna, Khokhar, Kramer, Kramer, Krishnan, Krishnan, Kuo, Kuo, Kuo, Kuo, Kuo, Kuo, Kuo, Kuo, Kuzell, Liu, Lottmann, Mariani, Matthew J Grainge, McAdams-Demarco, Meier, Merola, Michael Doherty, Obermayr, Obermayr, Pascual, Puig, Rathmann, Reynolds, Rho, Richette, Richette, Roddy, Rodriguez, Seminog, Shimizu, Terkeltaub, Vuorinen-Markkola, Wallace, Walley, Weiya Zhang, Yu, Yu, Yu, Zang, Zhang, Zhang, Zhu   +78 more
core   +2 more sources

Serum uric acid levels in older adults: Associations with clinical outcomes and implications for reference intervals in those aged 70 years and over

Arthritis Care &Research, Accepted Article.
Objectives Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged 70 and older.
Amanda J Rickard, Cammie Tran, Hans G Schneider, Flavia M Cicuttini, Anita E Wluka, Ego Seeman, Johannes T Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain, David P Q Clark, Daniel Clayton‐Chubb, Andrew M Tonkin, Lawrence J Beilin, Robyn L Woods, John J McNeil   +15 more
wiley   +1 more source

Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila

Scientific Reports
Artificial sweeteners are highly sweet, non-nutritive compounds that have become increasingly popular over recent decades despite research suggesting that their consumption has unintended consequences. Specifically, there is evidence suggesting that some
Christian Arntsen, Jake Grenon, Isabelle Chauvel, Stéphane Fraichard, Stéphane Dupas, Jérôme Cortot, Kayla Audette, Pierre-Yves Musso, Molly Stanley   +8 more
doaj   +1 more source

Ultrasound in the diagnosis of calcium pyrophosphate dihydrate deposition disease. A systematic literature review and a meta-analysis [PDF]

, 2016
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Adinolfi, A., Bertoldi, I., Cimmino, M. A., Delle Sedie, A., Di Sabatino, V., Filippou, G, Filippucci, E., Frediani, B., Iagnocco, Annamaria, Picerno, V., Scirè, C. A., Sconfienza, L. M.   +11 more
core   +3 more sources