Results 71 to 80 of about 157,164 (243)

DUSP1 Mitigates MSU-Induced Immune Response in Gouty Arthritis Reinforcing Autophagy

Frontiers in Bioscience-Landmark
Background: Persistent hyperuricemia can lead to the generation and deposition of monosodium urate (MSU) crystals. This can trigger gouty arthritis (GA), which in turn induces inflammation.
Jing Nie, Hongbin Qiu
doaj   +1 more source

Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout. [PDF]

, 2019
ObjectiveLesinurad (LESU) is a selective urate reabsorption inhibitor approved at 200 mg daily for use with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in gout patients failing to achieve target serum urate on XOI. The aim of the study was
Baumgartner, Scott, Goldfarb, David S, Jalal, Diana, Pillinger, Michael, Saag, Kenneth G, Schechter, Bruce M, Terkeltaub, Robert, Valiyil, Ritu, White, William B   +8 more
core   +1 more source

Two-temperature Steady State Thermodynamics for a Radiation Field

, 2005
A candidate for a consistent steady state thermodynamics is constructed for a radiation field in vacuum sandwiched by two black bodies of different temperatures.
Bekkenstein, Bekkenstein, Binney, Dominguez-Cascante, Essex, Essex, Fort, Fort, Hawking, Hiromi Saida, Jou, Kim, Kim, Kippenhahn, Kondepudi, Landau, Ore, Rosen, Wildt   +18 more
core   +1 more source

Risk Factors in the Incidence of Gouty Arthritis in Masohi Town, Central Maluku Regency in 2010 [PDF]

, 2012
The gouty arthritis incidence rate in Masohi Townof Central Maluku Regency is 54 people based on the data from the general  hospital in Masohi. The aim of study was to find out the risk factor in the incidence of gouty arthritis in Masohi Town of ...
Amiruddin, R. (Ridwan), Arsin, A. A. (A), Talarima, B. (Bellytra)   +2 more
core   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Exploration of molecular biomarkers in ankylosing spondylitis transcriptomics

Frontiers in Immunology
BackgroundInflammation of the spine and sacroiliac joints is a hallmark of the chronic, progressive inflammatory illness known as ankylosing spondylitis (AS). The insidious onset and non-specific early symptoms of AS often lead to delays in diagnosis and
Yuanpiao Ni, Yuanpiao Ni, Linrui Zhong, Linrui Zhong, Yanhui Li, Yanhui Li, Zeng Zhang, Zeng Zhang, Bin Ming, Bin Ming, Yufeng Qing, Yufeng Qing, Quanbo Zhang, Quanbo Zhang   +13 more
doaj   +1 more source

Landau-Lifshitz hierarchy and infinite dimensional Grassmann variety

, 2004
The Landau-Lifshitz equation is an example of soliton equations with a zero-curvature representation defined on an elliptic curve. This equation can be embedded into an integrable hierarchy of evolution equations called the Landau-Lifshitz hierarchy ...
Takasaki, Kanehisa
core   +1 more source

Association of Clonal Hematopoiesis with Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA)
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Management of Gout in the United States: A Claims‐based Analysis

ACR Open Rheumatology, 2020
Objective Gout is the most common inflammatory arthritis in the United States. Although numerous guidelines exist for the management of gout, they are not routinely implemented. This study evaluated the real‐world practice patterns in gout patients using
N. Lawrence Edwards, Naomi Schlesinger, Sanders Clark, Theresa Arndt, Peter E. Lipsky   +4 more
doaj   +1 more source

Validation of International Classification of Diseases (ICD) code‐based case definitions of immune checkpoint inhibitor associated inflammatory arthritis from administrative health data

Arthritis &Rheumatology, Accepted Article.
Background Immune checkpoint inhibitors (ICIs) for cancer can lead to immune‐related adverse events, including ICI‐associated inflammatory arthritis (ICI‐IA). There are no validated International Classification of Diseases (ICD) code–based case definitions for ICI‐IA.
Manar Elsayed, Zoe Hsu, Finlay A. McAlister, William D. Leslie, Lisa M. Lix, Sasha Bernatsky, Suzanne N Morin, Michelle M Graham, Aurore Fifi‐Mah, Shahin Jamal, Janet Roberts, Carrie Ye   +11 more
wiley   +1 more source