Results 41 to 50 of about 2,133 (160)

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, Volume 78, Issue 8, Page 1765-1775, August 2026.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Case Report: A rare case of bilateral middle ear tophaceous gout

Frontiers in Surgery
IntroductionHypacusia can be caused by various etiologies; however, hearing loss attributed to gouty tophi remains a rare occurrence. This case report presents, for the first time, a bilateral gouty tophi causing hearing impairment.Case presentationThis ...
Aybige Camurdan, Conrad Riemann, Frank Brasch, Ingo Todt   +3 more
doaj   +1 more source

Gouty tophi without hyperuricemia, an interesting case diagnosed by fine-needle aspiration cytology

Egyptian Rheumatology and Rehabilitation, 2017
Gout is a disorder of uric acid metabolism characterized by deposition of monosodium urate crystals in joint spaces or soft tissues. Gouty tophi can be the presenting feature of gout and can occur despite normal serum uric acid levels.
Debashish Bhattacharjee, Santosh K Mondal, Rudra Narayan Ray, Debjani Basu   +3 more
doaj   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Influence of contrast medium on tophus detection using dual-energy CT: phantom study and clinical illustration

European Radiology Experimental, 2023
Background To investigate the influence of iodinated contrast medium (ICM) on detection of monosodium urate (MSU) with dual-energy computed tomography (DECT) in two types of phantoms and demonstrate an example patient for clinical illustration.
Maximilian Kotlyarov, Jürgen Mews, Sevtap Tugce Ulas, Katharina Ziegeler, Bernd Hamm, Torsten Diekhoff   +5 more
doaj   +1 more source

Endoscopic Decompression of a Gouty Tophus at the Hand Dorsum

Arthroscopy Techniques, 2017
Medical treatment including lifestyle and dietary modifications and drug therapy remains the mainstay of treatment for gouty arthritis of the hand and wrist. Without proper and timely treatment, tophi develop approximately 10 years after the onset of the
Tun Hing Lui, M.B.B.S.(HK), F.R.C.S.(Edin), F.H.K.A.M., F.H.K.C.O.S.
doaj   +1 more source

Factors Associated With Intermittent and Constant Pain Patterns in People With Gout: A Cross‐Sectional Analysis

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective Although gout is traditionally conceptualized as an episodic disease characterized by acute flares and symptom‐free intercritical periods, some individuals report persistent joint pain that extends beyond flares. This cross‐sectional analysis aimed to explore factors associated with self‐reported pain patterns (constant vs intermittent) in ...
Sarah Stewart, Mia Clarke, Irene Zeng, Nicola Dalbeth, Tania Ka'ai, Karl Rudolph, Julie Collis, Nicola Kayes, David Rice   +8 more
wiley   +1 more source

A Rare Cause of Knee Pain in Gout Patients: Tophi of Patella

The Turkish Journal of Gastroenterology, 2015
Gout is a monosodium urate crystal deposit disease which generally occurs in middle-aged males and postmenopausal females. It is typically characterized by episodic acute and chronic arthritis, due to deposition of monosodium urate crystals in joints ...
Ayhan AŞKIN, Rahime İNCİ, Özlem AKAN, Seçil DEMİRDAL, Korhan BAYRAM   +4 more
doaj  

Tophaceous Gout and Renal Insufficiency: A New Solution for an Old Therapeutic Dilemma

Case Reports in Medicine, 2011
The prevalence of gout is increasing with increased life expectancy. Approximately half of the patients with gout have some degree of renal impairment. If both conditions persistently coexist, and in severe tophaceous gout, in particular, treatment has ...
Anne-Kathrin Tausche, Carsten Wunderlich, Martin Aringer   +2 more
doaj   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, Volume 78, Issue 6, Page 781-787, June 2026.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source