Results 81 to 90 of about 1,144,182 (342)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Discover SustainabilityThis study investigates the synergistic effects of energy alternatives, financial technology (FinTech), natural resources, and climate action within the BRICS nations, with a focus on achieving Sustainable Development Goal 13 (SDG13), which centers on ...
Md. Mominur Rahman +3 more
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Optimizing the health workforce for Universal Health Coverage: a framework for analysis and action
Human Resources for HealthBackground The health workforce or human resources for health (HRH) is the bedrock of an efficient healthcare system, and the consequences of HRH shortage are evident in poor health service delivery.
Gafar B. Alawode +4 more
doaj +1 more source
New European Banking Governance and Crisis of Democracy: Bank Restructuring and Privatization in Slovenia [PDF]
, 2019 Dóra Piroska, Ana Podvršič
openalex +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Haiti’s Army, Stabilization and Security Sector Governance
Stability : International Journal of Security and Development, 2016 Haiti’s long and difficult security sector reform (SSR) process has entered a new phase. The reinstatement of the Haitian armed forces, nearly 20 years after former President Jean-Bertrand Aristide disbanded them, adds a new set of actors and more ...
Geoff Burt
doaj +1 more source
Urban river governance through community movement to increase the adaptive capacity to climate change of the poor: a case study of Yogyakarta [PDF]
, 2020 Andie A. Wicaksono
openalex +1 more source