Results 41 to 50 of about 738,099 (338)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Profile and Effectiveness of Governing Body: A Study Among Christian Mission Hospitals in India

RGUHS Journal of Allied Health Sciences
Background Christian mission hospitals in India are still grappling with rising service needs rising expenses and inefficiencies in service design including antiquated care models.
Sneha Alex, Supreetha Castelino, John Varghese   +2 more
doaj   +1 more source

Board changes at IFOAM's World Board [PDF]

, 2009
At the recent elections the World Board of the organic movement’s international governing body, IFOAM, there was a major changing of the guard. Vanaja Ramprasad was one of the members newly elected to the ten-member World Board of the International ...
Paull, John
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The Engagement Level of Board Members and Associated Health Care Quality in Public Health Centers of Addis Ababa, Ethiopia, 2018

Risk Management and Healthcare Policy, 2021
Assalif Beyene Haile,1 Mesfin Beyene Haile,2 Abebe Mihretie Dagnaw,1 Eyosiyas Yeshialem Asefa,1 Michael Amera Tizazu1 1Midwifery Department, Health Science College, University of Debre Berhan, Debre Berhan, Ethiopia; 2Addis Ababa Health Bureau, Addis ...
Haile AB, Haile MB, Dagnaw AM, Asefa EY, Tizazu MA   +4 more
doaj  

Diversity in boardroom and debt financing: A case from China

Frontiers in Psychology, 2022
The study aims to explore the role of gender diversity in debt financing choices among Chinese listed firms. The study used the Chinese listed firm's data from 1991 to 2022 from the Chinese Stock Market return.
Xinbo Sun, Muneeb Ahmad, Kamran Tahir, Hammad Zafar   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Association Between Local Boards of Health Authority Over Budgets and PHAB Accreditation Standard Score

AJPM Focus, 2023
Introduction: This study examined the relationship between local board of health authority and local health departments’ budget-related activities and performance scores in the Public Health Accreditation Board standards while considering the governance ...
Oluwatosin O. Dada, PhD, MA, Betty Bekemeier, PhD, MPH, RN, FAAN, Abraham Flaxman, PhD, A.B. de Castro, PhD, MSN/MPH, RN, FAAN   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Managing unwarranted variation in hospital care – findings from a regional audit in Norway

Research in Health Services & Regions, 2023
Background/Aim There has been increasing focus and research over the past decades on defining, identifying, visualizing and reducing unwarranted clinical variation in clinical practice.
H. P. Eide, P. Barach, E. Søreide, C. Thoresen, O. Tjomsland   +4 more
doaj   +1 more source