Results 31 to 40 of about 168,503 (263)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Democratic Oversight of Government Hacking by Intelligence Agencies

Weizenbaum Journal of the Digital Society
Regulating intelligence services is a challenge for modern societies worldwide. Their very modus operandi relies on tight secrecy protocols for the information gathered, internationally and domestically.
André Ramiro
doaj   +1 more source

Future Prospects, Approaches, and the Government’s Role in the Development of a Hepatitis C Virus Vaccine

Pathogens, 2023
Developing a safe and effective vaccine against the hepatitis C virus (HCV) remains a top priority for global health. Despite recent advances in antiviral therapies, the high cost and limited accessibility of these treatments impede their widespread ...
Ashraf A. Tabll, Sayed S. Sohrab, Ahmed A. Ali, Ana Petrovic, Sabina Steiner Srdarevic, Stjepan Siber, Marija Glasnovic, Robert Smolic, Martina Smolic   +8 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The Determinants of Ethical Judgments at Local Government Agencies [PDF]

SHS Web of Conferences
To ensure survival during the digital technologies’ transformation, an organization must pay attention to ethics implemented in the organization and its employees.
Lestari Adini, Saud Ilham Maulana
doaj   +1 more source

Under the Influence of Politics: Mediatisation and politico-administrative systems in Scandinavia

Nordic Journal of Media Studies, 2020
This conceptual article extends three ongoing scholarly debates on the mediatisation of politics – the risk of media centrism, the tendency to see mediatisation as a linear process, and the preoccupation with elected officials.
Figenschou Tine Ustad, Fredriksson Magnus, Pallas Josef, Salomonsen Heidi Houlberg   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Electronic records management strategies by government agencies in Kenya

Record and Library Journal, 2019
Background of the study: Libraries have various challenges in maintaining their existence as information providers. Libraries must have support so that users do not turn to other services, have special strategies to connect themselves, establish good ...
Jonathan Limo, Tom Kwanya, Sally Chepchirchir   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source