Results 41 to 50 of about 268,036 (312)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Challenges beyond the Obligation of Performance Audit in the Government Agencies of Iran [PDF]

open access: yesحسابداری سلامت, 2014
Introduction: A great amount of evaluating performance and offering suggestions and solution to solve the problem of the government agencies is possible through performance audit. Moreover, implementing this type of auditing has been obliged in the fifth
M. Imani Barandagh
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Democratic Oversight of Government Hacking by Intelligence Agencies

open access: yesWeizenbaum Journal of the Digital Society
Regulating intelligence services is a challenge for modern societies worldwide. Their very modus operandi relies on tight secrecy protocols for the information gathered, internationally and domestically.
André Ramiro
doaj   +1 more source

A Content Analysis of e-Government Practice in Indonesia: The Case of Pontianak Municipality

open access: yesJPAS (Journal of Public Administration Studies), 2018
This paper aims to describee how the implementation of E-Government within public service provision in Pontianak City, West Kalimantan, Indonesia. This paper empirically investigated the implementation of e-Government by conducting a content analysis of ...
Syaiful Rahman
doaj   +1 more source

Designing and Testing a Model for Cyberloafing in Government Agencies [PDF]

open access: yesمطالعات مدیریت بهبود و تحول, 2020
Today, technology and its developments have become one of the most important elements of the strategic environment of the organization. What is causing concern among the managers of organizations is the prevalence of cyberloafing in organizations. Surely
Zahra Rahmati   +2 more
doaj   +1 more source

Electronic Government Act: Agencies Have Implemented Most Provisions, but Key Areas of Attention Remain [PDF]

open access: yes, 2012
A letter report issued by the Government Accountability Office with an abstract that begins "The Office of Management and Budget (OMB) and other agencies have taken steps to carry out leadership and organizational responsibilities as called for by the E ...
United States. Government Accountability Office.
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

ESCO Project for Buildings of Government Agencies in Thailand

open access: yesMATEC Web of Conferences, 2016
In Thailand, Department of Alternative Energy Development and Efficiency (DEDE) have organized the ESCO project to promote and encourage the use of machinery, materials and equipment having high efficiency for government buildings.
Prukvilailert Monchai, Wangskarn Prapat
doaj   +1 more source

Unlocking the agency of the governed: contestation and norm dynamics

open access: yesThird World Thematics: A TWQ Journal, 2017
International Relations (IR) research on the translation and appropriation of international norms emphasises both the role of local agency and the fundamental malleability of norms.
Zimmermann, L.   +2 more
openaire   +3 more sources

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