Results 51 to 60 of about 2,006,808 (290)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Do Donor Restrictions Affect Sustainability of Water and Sanitation Interventions? Results from a Pilot Survey [PDF]
, 2015 The Water, Sanitation and Hygiene (WASH) sector has had its challenges. Reasons for failure usually focus on technology, water users, community management committees, local government, national government policies and implementers (NGOs).
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
“Dream” and Poverty Alleviation
Mimbar, 2017 This research is motivated by the failure of Indonesian government in implementing its poverty alleviation. Poverty rate in Indonesia does not decrease although the government has implemented a complete strategy to address the problem.
Pajar Hatma Indra Jaya
doaj +1 more source
Industrial policy for the medium to long-term [PDF]
, 2014 This report reviews the market failure and systems failure rationales for industrial policy and assesses the evidence on part experience of industrial policy in the UK. In the light of this, it reviews options for reshaping the design and delivery of
Crafts, N. F. R., Hughes, Alan
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
State Collapse: Government Failure in Gaddafi's Libya
PopulikaThis article discusses the background and conditions of Libya before and during the reign of Muammar al-Gaddafi, which ended with the fall of his regime in 2011. Libya has a strong economy thanks to its oil resources, but Gaddafi's rule was characterized
Carelia Pradita Putri Hariyanti +2 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Jurnal Presipitasi, 2019 During the dry season there was a scarcity of the availability of clean water in several Central Java province (Wonogiri, Sukoharjo, Karanganyar Disrict and Surakarta City), including Wosusokas Regional Region, so the government often drops clean water ...
Kartika Hapsari Sutantiningrum +1 more
doaj +1 more source
The Case for an Orderly Resolution Regime for Systemically-Important Financial Institutions [PDF]
, 2009 Outlines the need to give the government authority to resolve a financial institution if its failure poses serious systemic risks, examines concerns and counterproposals, and offers recommendations and considerations for designing such a ...
H. Rodgin Cohen, Morris Goldstein
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