Results 71 to 80 of about 2,006,808 (290)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Ekonomi politik media : inefisiensi media terkontrol kekuatan politik dalam pemilihan umum
LekturAbstrak Media memiliki peran sentral dalam ekonomi politik, menciptakan hubungan kompleks antara kekuasaan politik, ekonomi, dan teknologi informasi. Makalah ini menguraikan landasan sejarah dan perkembangan ekonomi politik media serta mempertimbangkan ...
Ersina Shinta Baskara
doaj +1 more source
Historical regulation of Victoria's water sector: A case of government failure? [PDF]
This paper analyses the role of government failure in Victoria’s water sector between 1905 and 1984 as evidenced in the rise of in-stream salinity. It will be shown that high levels of salinity can, in part, be attributed to regulatory failure for two ...
Harris, E.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Failed States Status in Contemporary International Law [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2013 Since the end of the cold war, the International Community has become increasingly preoccupied with a phenomenon giving rise to a wide range of humanitarian, legal and security strains generally known as ‘State failure’.
Aramesh Shahbazi, Khadijeh Javadi Sharif
doaj
Government Intervention as an Optimal Response to Government (not Market!) Failure [PDF]
This paper provides a theory of government intervention, such as government ownership, regulation, mandatory public schooling, subsidies, and industrial policy, as an optimal policy response due to the inability to commit not to expropriate private ...
Adriano Rampini, Alberto Bisin
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Remaking Local Government: Success and Failure Under Indiana’s Government Modernization Act
Journal of Public and Nonprofit Affairs, 2017 During the period of 2008 to 2012, four consolidation attempts occurred under Indiana’s Government Modernization Act: two proposing city–county consolidation and two proposing town–township consolidation.
Charles D. Taylor +2 more
doaj
The perils of semi-presidentialism. Are they exaggerated? [PDF]
, 2008 There is a standard academic consensus that semi-presidentialism is perilous for new democracies. In particular, this is because semi-presidential countries run the risk of experiencing difficult periods of ‘cohabitation’ between a president and a prime ...
Elgie, Robert
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source