Results 91 to 100 of about 1,962,391 (308)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The impending sell-off of nearly 10% of the UK's forest area by the government could have detrimental consequences for conservation and our ‘Green’ reputation [PDF]
, 2010 The government has recently announced plans to reform the Forestry Commission and sell off vast tracts of forest land, in the biggest transfer of land ownership since the Second World War.
Hancock, Avery
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Aquaculture potentials and investment opportunity in shrimps and prawns farming in Nigeria [PDF]
, 2005 Some aspects of the aquaculture potentials and investment opportunity in shrimps and prawn farming in Nigeria were overviewed. This paper presents the breeding pattern, spawner availability, culture water-type and properties, feeds and feeding regimes ...
Ibiyo, L.M.O. +2 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The market to the rescue? The promise - and price - of the new social security investment proposals [PDF]
Three new plans for reforming Social Security financing recommend investing a portion of future payroll deductions in the financial markets. The plans aim to shore up Social Security's trust fund, improve individual returns, and enhance national saving ...
Susan Miller
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Shared Modes of Compensation and Firm Performance: UK Evidence [PDF]
This paper examines the use and consequences of shared compensation plans (profit sharing, profit related pay, SAYE schemes and company stock option plans) in a sample of UK workplaces and firms in the 1990s.
Martin J. Conyon, Richard B. Freeman
core +3 more sources
Saying NO To the Mega Prison [PDF]
, 2018 This activist contribution draws upon the issues emphasised by abolitionist activists in their struggles throughout 2017 (and before) to challenge government plans to build six new mega prisons in England and Wales by 2020.
Scott, David
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source