Results 81 to 90 of about 216,366 (291)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Risk preference, government regulation, and the sustainability of crop straw resource utilization—based on research data from Liaoning Province, China

open access: yesFrontiers in Environmental Science
IntroductionGlobal crop straw production has increased sharply, leading to serious challenges in straw burning and disposal. The unsustainable practice of open burning wastes valuable renewable resources and poses significant environmental threats, such ...
Te Huang, Yu Guo, Jing Zhou, Liqun Xiu
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A study of government regulation’s strategy for solving the algorithmic black-box puzzle of digital platforms: a complex network-based perspective

open access: yesFrontiers in Physics
With the iteration of information technology and the enhancement of the arithmetic power of huge amounts of data, the economic model of digital platforms driven by data has become an important carrier of digital trade and digital economic development. By
Gehui Zhu   +3 more
doaj   +1 more source

Government regulation of private health insurance. [PDF]

open access: yesCochrane Database Syst Rev, 2021
Motaze NV   +4 more
europepmc   +1 more source

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