Results 61 to 70 of about 5,411,240 (298)

High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models

Nature Communications
Missense mutations in the 12th codon of KRAS are key drivers of lung cancer, with glycine-to-cysteine (G12C) and glycine-to-aspartic acid (G12D) substitutions being among the most prevalent.
Juan Carlos Álvarez-Pérez, Juan Sanjuán-Hidalgo, Alberto M. Arenas, Ivan Hernández-Navas, Maria S. Benitez‑Cantos, Alvaro Andrades, Silvia Calabuig-Fariñas, Eloisa Jantus-Lewintre, Luis Paz-Ares, Irene Ferrer, Pedro P. Medina   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The demographic problems of the Pskov region and the main approaches to solving them at the level of the regional state authorities [PDF]

Baltic Region, 2010
This article analyses the demographic problems of the Pskov region. The authors propose a system of government regulation of demographic processes in view of the functions of the regional executive authorities.
Yelsukov Mikhail, Kashina Marina, Klyuev Anatoli   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Qualitative assessment of a Context of Consumption Framework to inform regulation of cigarette pack design in the U.S.

Tobacco Induced Diseases, 2018
Introduction Researchers and regulators need to know how changes to cigarette packages can influence population health. We sought to advance research on the role of cigarette packaging by assessing a theory-informed framework from the fields of design ...
Joseph G. L. Lee, Paige E. Averett, Tiffany Blanchflower, Kyle R. Gregory   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Protection against Government Takings: Compensation for Regulation? [PDF]

The paper responds to recent debate in New Zealand on the power of the government to take private property, directly or through regulatory constraints. This aspect of regulation has received less attention in New Zealand than it warrants.
Kevin Guerin
core  

GOVERNMENT REGULATION OF HOUSING.

Хабаршысы. Экономика сериясы, 2015
В статье рассматривается современное состояние жилищного сектора и роль государственных программ в обеспечении жильем народа Республики Казахстан.
S. Orakbaeva
doaj  

AN ANALYSIS OF TAYMIYYAH’S PERSPECTIVE ON GOVERNMENT REGULATION AFFORDABILITY IN INDONESIA

Politik Indonesia: Indonesian Political Science Review
One of the primary roles of the government is to regulate the private sector. Concerns regarding housing affordability are widespread among low- and middle-income households across both urban and rural areas in Indonesia, with many struggling to ...
Ali Musa Harahap
doaj   +1 more source