Results 41 to 50 of about 304,684 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Determinantes de la eficiencia del gasto público sanitario en Latinoamérica: Una evaluación de frontera estocástica

Latin American Research Review, 2023
El objetivo de este artículo es establecer el nivel de eficiencia del gasto público sanitario en América Latina y comprobar su relación con determinadas características institucionales como calidad regulatoria, participación del sector privado ...
Diego E. Pinilla-Rodríguez, Juan de Dios Jiménez-Aguilera, Roberto Montero-Granados   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Generic regulation model: the evolution of a practical theory for e‐government

, 2011
Purpose - This paper presents a new theoretical model (the Generic Regulation Model - GRM) which is aimed for e-government development. There is a need for such a generic model in order to describe and analyse the regulation that occurs in the ...
Goldkuhl, Göran,, Göran Goldkuhl
core   +1 more source

TUSC7 expression and mutational profile define its potential as a diagnostic and therapeutic biomarker in non-small cell lung cancer

Biomarker Research
Non-small cell lung cancer (NSCLC) accounts for ~85% of lung cancer cases and remains the leading cause of cancer-related mortality worldwide. Despite advances in targeted therapies, early diagnosis and prediction of treatment response remain major ...
Pablo Martin-Lopez, Marta Cuadros, Fernando Montenegro-Elvira, Alberto M. Arenas, María Palomino, Claudia Loidi, Mónica Saiz, Pedro P. Medina   +7 more
doaj   +1 more source

Economic analysis of the performance of Russian manufacturers of equipment for the dairy industry

RUDN Journal of Economics, 2023
The collapse of the USSR led not only to the formation of 15 independent republics, the emergence of the CIS, but also to the rupture of those complex long-term stable cooperative ties between the countries that have been formed and developed for more ...
Mikhail M. Kulumbegov
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Macroeconomic effects of regulation and deregulation

Mенаџмент у хотелијерству и туризму, 2013
The role of government in market economies is being discussed for more than two centuries. This problem is particularly topical in most transition countries, where the transition from a totalitarian political system and controlled economy to a multiparty,
Marija Lakićević, Sonja Milutinović, Milica Žarevac   +2 more
doaj   +4 more sources

Entry barriers and tripartite evolutionary game analysis of seawater desalination under the government regulation in China

Frontiers in Marine Science, 2023
Seawater desalination is a new promising marine industry and an important way to supplement the shortage of land water resources and promote the efficient use of seawater resources. Currently, the global desalination industry is rapidly developing.
Mingbao Chen, Mingbao Chen, Mingbao Chen, Zhibin Xu, Zhibin Xu, Yuhao Wang, Yuhao Wang   +6 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source