Results 51 to 60 of about 1,745,962 (311)

North to the Future of the Right to Bear Arms: Analyzing the Alaska Firearms Freedom Act and Applying Firearm Localism to Alaska [PDF]

open access: yes, 2016
The Second Amendment has gone from a rarely invoked constitutional provision to being one of the most hotly contested and politically charged protections of the Bill of Rights.
Hill, John
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Descriptive Study Of Public Services Quality In Surabaya [PDF]

open access: yes, 2011
Currently, the service becomes a very important factor, not leastin the services sector, government or public service. The government has made various efforts for better public services to be from time to time as stipulated by Regulation of the ...
Megawati, Veny   +2 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Viewpoint of COVID-19 in Africa and Latin America

open access: yesTurkish Journal of Internal Medicine, 2020
The spread of COVID-19 across the African continent and Latin American region is of great concern due to several influencing factors. Large and densely populated areas and townships with widespread poverty and high migration are the most vulnerable ...
Dominique Fournier, Ernest Herbert
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models

open access: yesNature Communications
Missense mutations in the 12th codon of KRAS are key drivers of lung cancer, with glycine-to-cysteine (G12C) and glycine-to-aspartic acid (G12D) substitutions being among the most prevalent.
Juan Carlos Álvarez-Pérez   +10 more
doaj   +1 more source

Book review: media regulation: governance and the interests of citizens and consumers by Peter Lunt and Sonia Livingstone [PDF]

open access: yes, 2012
In Media Regulation, Peter Lunt and Sonia Livingstone examine the challenges of regulation in the global mediated sphere. The book explores the way that regulation affects the relations between government, the media and communications market, civil ...
Iosifidis, Petros
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Zoning’s Centennial: A Complete Account of the Evolution of Zoning into a Robust System of Land Use Law—1916-2016 (Part IV) [PDF]

open access: yes, 2016
Fracking is happening and local governments are subjected to many of its associated risks. They either need to act, or know—clearly and convincingly—why they should not. The federal government has stopped far short of comprehensive regulation of fracking;
Nolon, John R
core   +4 more sources

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