Results 101 to 110 of about 869,766 (268)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

СМЕНА ПАРАДИГМЫ РЕГИОНАЛЬНОЙ ПОЛИТИКИ В XXI ВЕКЕ (ЗАРУБЕЖНЫЙ ОПЫТ И РЕКОМЕНДАЦИИ ДЛЯ КАЗАХСТАНА)

open access: yesЭкономика: стратегия и практика, 2019
The purpose of this research is to investigate the evolution of regional policy, models existing theory and practice, mechanisms and approaches for spatial development, substantiation of the most acceptable paradigm of the formation and implementation of
N. K. Nurlanova
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perron–Support Governance

open access: yes
Perron Support Governance formalizes the governing principle that determines admissibility, stability, and control in near-critical positive-operator systems. The paper shows that all admissible actions, perturbations, and observer interactions are constrained by their projection onto the Perron–Frobenius eigenstructure of basin-restricted operators ...
openaire   +3 more sources

Government Support for Forests; The Government Relief Program.

open access: yes, 2002
Les tempêtes des 26 et 28 décembre 1999 ont causé des chablis d'une ampleur sans précédent en France. Un plan gouvernemental pour la forêt française a été rendu public par le gouvernement le 12 janvier 2000, puis complété par diverses mesures en fonction des problèmes identifiés.
Barthod, Christian, Barrillon, Anne
openaire   +1 more source

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