Results 121 to 130 of about 10,075,675 (301)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Healthcare Infrastructure, Policy Support & Government Initiatives

open access: yesNational Board of Examinations Journal of Medical Sciences, 2023
Minu Bajpai, Abhijat Sheth
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Sustainable tourism experiences: the role of digital technology and government support in creating tourists’ memorable experiences

open access: yesCogent Business & Management
Sustainability practices in the tourism industry offer significant benefits to destinations, particularly when supported by digital technology and government involvement. This study investigates how sustainable tourism experiences influence the memorable
Regina Jokom   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

An International Comparison of the Effects of Government Agricultural Support on Food Budget Shares [PDF]

open access: yes
This study evaluates econometrically the effect of government support to agriculture on a measure of the affordability of food in 10 Organization for Economic Cooperation and Development (OECD) countries.
Coble, Keith H., Miller, J. Corey
core  

Perron–Support Governance

open access: yes
Perron Support Governance formalizes the governing principle that determines admissibility, stability, and control in near-critical positive-operator systems. The paper shows that all admissible actions, perturbations, and observer interactions are constrained by their projection onto the Perron–Frobenius eigenstructure of basin-restricted operators ...
openaire   +3 more sources

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