Results 151 to 160 of about 13,350,834 (357)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Healthcare Infrastructure, Policy Support & Government Initiatives

open access: yesNational Board of Examinations Journal of Medical Sciences, 2023
Minu Bajpai, Abhijat Sheth
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Fiscal Year 2006 Budget Request: U.S. Government Accountability Office [PDF]

open access: yes, 2005
Testimony issued by the Government Accountability Office with an abstract that begins "We are grateful to the Congress for providing us with the support and resources that have helped us in our quest to be a world-class professional services organization.
United States. Government Accountability Office.
core  

Government support and commitment to university-level public health education, research and workforce development is critical. [PDF]

open access: yesAust N Z J Public Health, 2022
Gurnett T   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Local Government Excellence Programme prospectus – overview [PDF]

open access: yes, 2016
The 2015 New Zealand Local Government Survey found residents and businesses had a low awareness of the full services councils provide and the value they bring.
Local Government New Zealand
core  

СМЕНА ПАРАДИГМЫ РЕГИОНАЛЬНОЙ ПОЛИТИКИ В XXI ВЕКЕ (ЗАРУБЕЖНЫЙ ОПЫТ И РЕКОМЕНДАЦИИ ДЛЯ КАЗАХСТАНА)

open access: yesЭкономика: стратегия и практика, 2019
The purpose of this research is to investigate the evolution of regional policy, models existing theory and practice, mechanisms and approaches for spatial development, substantiation of the most acceptable paradigm of the formation and implementation of
N. K. Nurlanova
doaj  

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