Results 161 to 170 of about 13,350,834 (357)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Debt is not a dirty word: the role and use of debt in local government [PDF]

open access: yes, 2014
This research suggests the sensible use of debt by local councils can address infrastructure backlogs and positively support sustainable local communities and organisation performance.
John Comrie
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Программа по алиментам в штате Орегон: издание подготовлено по заказу Oregon Child Support Program, организацией The Department of Justice, Division of Child Support

open access: yes, 2004
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF title page (viewed on Feb.

core  

Perron–Support Governance

open access: yes
Perron Support Governance formalizes the governing principle that determines admissibility, stability, and control in near-critical positive-operator systems. The paper shows that all admissible actions, perturbations, and observer interactions are constrained by their projection onto the Perron–Frobenius eigenstructure of basin-restricted operators ...
openaire   +3 more sources

Government Support for Forests; The Government Relief Program.

open access: yes, 2002
Les tempêtes des 26 et 28 décembre 1999 ont causé des chablis d'une ampleur sans précédent en France. Un plan gouvernemental pour la forêt française a été rendu public par le gouvernement le 12 janvier 2000, puis complété par diverses mesures en fonction des problèmes identifiés.
Barthod, Christian, Barrillon, Anne
openaire   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

An International Comparison of the Effects of Government Agricultural Support on Food Budget Shares

open access: yes
This study evaluates econometrically the effect of government support to agriculture on a measure of the affordability of food in 10 Organization for Economic Cooperation and Development (OECD) countries.
Coble, Keith H., Miller, J. Corey
core  

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