Results 71 to 80 of about 10,075,675 (301)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Australian Tourism Small-Medium Enterprises: Challenges Engaging with Government Support
The Australian tourism industry is predominantly composed of micro, small and medium-sized enterprises, which make a substantial contribution to national wellbeing through their impact on gross domestic product (GDP), employment and socio-cultural ...
King, Kerrie
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Local Government Regional Management Plan - Northern Region
, 2012 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).'The Plan is set out in five sections. Background provides an overview of legislative requirements of Regional Management Plans.
Local Government Support Unit
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Citizens’ support for government spending on Science and Technology
, 2013 This paper analyses public support for government spending on science and technology (S&T) and its determinants. It constructs hypotheses based on previous findings from two streams of research: public preferences for government spending and public ...
Sanz Menéndez, Luis +2 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Catalan government popularity. An example of economic effects on sub-national government support [PDF]
The aim of this essay is to deal with economic voting in contexts of multilevel governance and to be a contribution to the debate on attribution of responsibilities in popularity functions literature.
Clara Riba, Aida Díaz
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Literature Review: policies adopted to support a healthy retail sector and retail led regeneration and the impact of retail on the regeneration of town centres and local high streets [PDF]
, 2009 Communities Analytical Services, on behalf of the Regeneration Division of the Scottish Government, commissioned the Institute for Retail Studies at the University of Stirling to provide a literature review of the policies adopted to support a healthy ...
Sparks, Leigh, Findlay, Anne
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